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Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca(2+)-handling proteins
The endoplasmic reticulum is a heterogeneous compartment with respect to the distribution of its Ca(2+)-handling proteins, namely the Ca(2+)-binding proteins, the Ca(2+) pumps and the Ca(2+) release channels. The nonuniform distribution of these proteins may explain the functional heterogeneity of t...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173736/ https://www.ncbi.nlm.nih.gov/pubmed/12591911 http://dx.doi.org/10.1083/jcb.200207136 |
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author | Papp, S. Dziak, E. Michalak, M. Opas, M. |
author_facet | Papp, S. Dziak, E. Michalak, M. Opas, M. |
author_sort | Papp, S. |
collection | PubMed |
description | The endoplasmic reticulum is a heterogeneous compartment with respect to the distribution of its Ca(2+)-handling proteins, namely the Ca(2+)-binding proteins, the Ca(2+) pumps and the Ca(2+) release channels. The nonuniform distribution of these proteins may explain the functional heterogeneity of the endoplasmic reticulum, such as the generation of spatially complex Ca(2+) signals, Ca(2+) homeostasis, and protein folding and quality control. |
format | Text |
id | pubmed-2173736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21737362008-05-01 Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca(2+)-handling proteins Papp, S. Dziak, E. Michalak, M. Opas, M. J Cell Biol Mini-Review The endoplasmic reticulum is a heterogeneous compartment with respect to the distribution of its Ca(2+)-handling proteins, namely the Ca(2+)-binding proteins, the Ca(2+) pumps and the Ca(2+) release channels. The nonuniform distribution of these proteins may explain the functional heterogeneity of the endoplasmic reticulum, such as the generation of spatially complex Ca(2+) signals, Ca(2+) homeostasis, and protein folding and quality control. The Rockefeller University Press 2003-02-17 /pmc/articles/PMC2173736/ /pubmed/12591911 http://dx.doi.org/10.1083/jcb.200207136 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Mini-Review Papp, S. Dziak, E. Michalak, M. Opas, M. Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca(2+)-handling proteins |
title | Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca(2+)-handling proteins |
title_full | Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca(2+)-handling proteins |
title_fullStr | Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca(2+)-handling proteins |
title_full_unstemmed | Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca(2+)-handling proteins |
title_short | Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca(2+)-handling proteins |
title_sort | is all of the endoplasmic reticulum created equal? the effects of the heterogeneous distribution of endoplasmic reticulum ca(2+)-handling proteins |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173736/ https://www.ncbi.nlm.nih.gov/pubmed/12591911 http://dx.doi.org/10.1083/jcb.200207136 |
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