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PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure
The type 1 ryanodine receptor (RyR1) on the sarcoplasmic reticulum (SR) is the major calcium (Ca(2+)) release channel required for skeletal muscle excitation–contraction (EC) coupling. RyR1 function is modulated by proteins that bind to its large cytoplasmic scaffold domain, including the FK506 bind...
Autores principales: | Reiken, Steven, Lacampagne, Alain, Zhou, Hua, Kherani, Aftab, Lehnart, Stephan E., Ward, Chris, Huang, Fannie, Gaburjakova, Marta, Gaburjakova, Jana, Rosemblit, Nora, Warren, Michelle S., He, Kun-lun, Yi, Geng-hua, Wang, Jie, Burkhoff, Daniel, Vassort, Guy, Marks, Andrew R. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173774/ https://www.ncbi.nlm.nih.gov/pubmed/12629052 http://dx.doi.org/10.1083/jcb.200211012 |
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