Axonal transport of membranous and nonmembranous cargoes: a unified perspective

Membranous and nonmembranous cargoes are transported along axons in the fast and slow components of axonal transport, respectively. Recent observations on the movement of cytoskeletal polymers in axons suggest that slow axonal transport is generated by fast motors and that the slow rate is due to ra...

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Detalles Bibliográficos
Autor principal: Brown, Anthony
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173776/
https://www.ncbi.nlm.nih.gov/pubmed/12642609
http://dx.doi.org/10.1083/jcb.200212017
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author Brown, Anthony
author_facet Brown, Anthony
author_sort Brown, Anthony
collection PubMed
description Membranous and nonmembranous cargoes are transported along axons in the fast and slow components of axonal transport, respectively. Recent observations on the movement of cytoskeletal polymers in axons suggest that slow axonal transport is generated by fast motors and that the slow rate is due to rapid movements interrupted by prolonged pauses. This supports a unified perspective for fast and slow axonal transport based on rapid movements of diverse cargo structures that differ in the proportion of the time that they spend moving. A Flash feature (http://www.jcb.org/cgi/content/full/jcb.200212017/DC1) accompanies this Mini-Review.
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spelling pubmed-21737762008-05-01 Axonal transport of membranous and nonmembranous cargoes: a unified perspective Brown, Anthony J Cell Biol Mini-Review Membranous and nonmembranous cargoes are transported along axons in the fast and slow components of axonal transport, respectively. Recent observations on the movement of cytoskeletal polymers in axons suggest that slow axonal transport is generated by fast motors and that the slow rate is due to rapid movements interrupted by prolonged pauses. This supports a unified perspective for fast and slow axonal transport based on rapid movements of diverse cargo structures that differ in the proportion of the time that they spend moving. A Flash feature (http://www.jcb.org/cgi/content/full/jcb.200212017/DC1) accompanies this Mini-Review. The Rockefeller University Press 2003-03-17 /pmc/articles/PMC2173776/ /pubmed/12642609 http://dx.doi.org/10.1083/jcb.200212017 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Mini-Review
Brown, Anthony
Axonal transport of membranous and nonmembranous cargoes: a unified perspective
title Axonal transport of membranous and nonmembranous cargoes: a unified perspective
title_full Axonal transport of membranous and nonmembranous cargoes: a unified perspective
title_fullStr Axonal transport of membranous and nonmembranous cargoes: a unified perspective
title_full_unstemmed Axonal transport of membranous and nonmembranous cargoes: a unified perspective
title_short Axonal transport of membranous and nonmembranous cargoes: a unified perspective
title_sort axonal transport of membranous and nonmembranous cargoes: a unified perspective
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173776/
https://www.ncbi.nlm.nih.gov/pubmed/12642609
http://dx.doi.org/10.1083/jcb.200212017
work_keys_str_mv AT brownanthony axonaltransportofmembranousandnonmembranouscargoesaunifiedperspective

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