Mycobacterium and the coat of many lipids

Pathogenic Mycobacterium reside inside vacuoles in their host macrophages. These vacuoles fail to fuse with lysosomes yet interact with early endosomes. Glycoconjugates released by the intracellular bacilli traffic through the host cell and are released through exocytosis. These molecules represent...

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Detalles Bibliográficos
Autores principales: Russell, David G., Mwandumba, Henry C., Rhoades, Elizabeth E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Mini-Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173834/
https://www.ncbi.nlm.nih.gov/pubmed/12147678
http://dx.doi.org/10.1083/jcb.200205034
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author Russell, David G.
Mwandumba, Henry C.
Rhoades, Elizabeth E.
author_facet Russell, David G.
Mwandumba, Henry C.
Rhoades, Elizabeth E.
author_sort Russell, David G.
collection PubMed
description Pathogenic Mycobacterium reside inside vacuoles in their host macrophages. These vacuoles fail to fuse with lysosomes yet interact with early endosomes. Glycoconjugates released by the intracellular bacilli traffic through the host cell and are released through exocytosis. These molecules represent both antigens for immune recognition and modulators of immune function. The molecules play key roles in the induction and maintenance of the granuloma, a tissue response that limits bacterial spread yet ensures persistence of the infection.
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spelling pubmed-21738342008-05-01 Mycobacterium and the coat of many lipids Russell, David G. Mwandumba, Henry C. Rhoades, Elizabeth E. J Cell Biol Mini-Reviews Pathogenic Mycobacterium reside inside vacuoles in their host macrophages. These vacuoles fail to fuse with lysosomes yet interact with early endosomes. Glycoconjugates released by the intracellular bacilli traffic through the host cell and are released through exocytosis. These molecules represent both antigens for immune recognition and modulators of immune function. The molecules play key roles in the induction and maintenance of the granuloma, a tissue response that limits bacterial spread yet ensures persistence of the infection. The Rockefeller University Press 2002-08-05 /pmc/articles/PMC2173834/ /pubmed/12147678 http://dx.doi.org/10.1083/jcb.200205034 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Mini-Reviews
Russell, David G.
Mwandumba, Henry C.
Rhoades, Elizabeth E.
Mycobacterium and the coat of many lipids
title Mycobacterium and the coat of many lipids
title_full Mycobacterium and the coat of many lipids
title_fullStr Mycobacterium and the coat of many lipids
title_full_unstemmed Mycobacterium and the coat of many lipids
title_short Mycobacterium and the coat of many lipids
title_sort mycobacterium and the coat of many lipids
topic Mini-Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173834/
https://www.ncbi.nlm.nih.gov/pubmed/12147678
http://dx.doi.org/10.1083/jcb.200205034
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