Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF

BACKGROUND: Enhanced osteoblast-dependent osteoclastogenesis due to inhibition of Wnt/β-catenin signaling in bone morphogenic protein (BMP)-driven osteoprogenitors has been repeatedly implicated in the natural history of cancer-associated osteolytic lesions, but the mechanism of this bone loss is po...

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Detalles Bibliográficos
Autores principales: Fujita, Ken-ichi, Janz, Siegfried
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173906/
https://www.ncbi.nlm.nih.gov/pubmed/17971207
http://dx.doi.org/10.1186/1476-4598-6-71

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173906/
https://www.ncbi.nlm.nih.gov/pubmed/17971207
http://dx.doi.org/10.1186/1476-4598-6-71

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