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Importance of a C-Terminal Conserved Region of Chk1 for Checkpoint Function

BACKGROUND: The protein kinase Chk1 is an essential component of the DNA damage checkpoint pathway. Chk1 is phosphorylated and activated in the fission yeast Schizosaccharomyces pombe when cells are exposed to agents that damage DNA. Phosphorylation, kinase activation, and nuclear accumulation are e...

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Detalles Bibliográficos
Autores principales:	Palermo, Carmela, Hope, Justin C., Freyer, Greg A., Rao, Hui, Walworth, Nancy C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173936/ https://www.ncbi.nlm.nih.gov/pubmed/18183307 http://dx.doi.org/10.1371/journal.pone.0001427

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