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Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis
BACKGROUND: The human pathogen Streptococcus pyogenes produces an endoglycosidase, EndoS that hydrolyzes the chitobiose core of the asparagine-linked glycan on the heavy chain of human IgG. IgG-binding to Fc gamma receptors (FcγR) on leukocytes triggers effector functions including phagocytosis, oxi...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173940/ https://www.ncbi.nlm.nih.gov/pubmed/18183294 http://dx.doi.org/10.1371/journal.pone.0001413 |