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Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome

We describe an unusual mechanism for organelle division. In the yeast Yarrowia lipolytica, only mature peroxisomes contain the complete set of matrix proteins. These mature peroxisomes assemble from several immature peroxisomal vesicles in a multistep pathway. The stepwise import of distinct subsets...

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Autores principales: Guo, Tong, Kit, Yuriy Y., Nicaud, Jean-Marc, Le Dall, Marie-Therese, Sears, S. Kelly, Vali, Hojatollah, Chan, Honey, Rachubinski, Richard A., Titorenko, Vladimir I.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173948/
https://www.ncbi.nlm.nih.gov/pubmed/14504266
http://dx.doi.org/10.1083/jcb.200305055
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author Guo, Tong
Kit, Yuriy Y.
Nicaud, Jean-Marc
Le Dall, Marie-Therese
Sears, S. Kelly
Vali, Hojatollah
Chan, Honey
Rachubinski, Richard A.
Titorenko, Vladimir I.
author_facet Guo, Tong
Kit, Yuriy Y.
Nicaud, Jean-Marc
Le Dall, Marie-Therese
Sears, S. Kelly
Vali, Hojatollah
Chan, Honey
Rachubinski, Richard A.
Titorenko, Vladimir I.
author_sort Guo, Tong
collection PubMed
description We describe an unusual mechanism for organelle division. In the yeast Yarrowia lipolytica, only mature peroxisomes contain the complete set of matrix proteins. These mature peroxisomes assemble from several immature peroxisomal vesicles in a multistep pathway. The stepwise import of distinct subsets of matrix proteins into different immature intermediates along the pathway causes the redistribution of a peroxisomal protein, acyl-CoA oxidase (Aox), from the matrix to the membrane. A significant redistribution of Aox occurs only in mature peroxisomes. Inside mature peroxisomes, the membrane-bound pool of Aox interacts with Pex16p, a membrane-associated protein that negatively regulates the division of early intermediates in the pathway. This interaction inhibits the negative action of Pex16p, thereby allowing mature peroxisomes to divide.
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spelling pubmed-21739482008-05-01 Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome Guo, Tong Kit, Yuriy Y. Nicaud, Jean-Marc Le Dall, Marie-Therese Sears, S. Kelly Vali, Hojatollah Chan, Honey Rachubinski, Richard A. Titorenko, Vladimir I. J Cell Biol Article We describe an unusual mechanism for organelle division. In the yeast Yarrowia lipolytica, only mature peroxisomes contain the complete set of matrix proteins. These mature peroxisomes assemble from several immature peroxisomal vesicles in a multistep pathway. The stepwise import of distinct subsets of matrix proteins into different immature intermediates along the pathway causes the redistribution of a peroxisomal protein, acyl-CoA oxidase (Aox), from the matrix to the membrane. A significant redistribution of Aox occurs only in mature peroxisomes. Inside mature peroxisomes, the membrane-bound pool of Aox interacts with Pex16p, a membrane-associated protein that negatively regulates the division of early intermediates in the pathway. This interaction inhibits the negative action of Pex16p, thereby allowing mature peroxisomes to divide. The Rockefeller University Press 2003-09-29 /pmc/articles/PMC2173948/ /pubmed/14504266 http://dx.doi.org/10.1083/jcb.200305055 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Guo, Tong
Kit, Yuriy Y.
Nicaud, Jean-Marc
Le Dall, Marie-Therese
Sears, S. Kelly
Vali, Hojatollah
Chan, Honey
Rachubinski, Richard A.
Titorenko, Vladimir I.
Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome
title Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome
title_full Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome
title_fullStr Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome
title_full_unstemmed Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome
title_short Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome
title_sort peroxisome division in the yeast yarrowia lipolytica is regulated by a signal from inside the peroxisome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173948/
https://www.ncbi.nlm.nih.gov/pubmed/14504266
http://dx.doi.org/10.1083/jcb.200305055
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