Notch1 control of oligodendrocyte differentiation in the spinal cord

We have selectively inhibited Notch1 signaling in oligodendrocyte precursors (OPCs) using the Cre/loxP system in transgenic mice to investigate the role of Notch1 in oligodendrocyte (OL) development and differentiation. Early development of OPCs appeared normal in the spinal cord. However, at embryo...

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Autores principales: Genoud, Stéphane, Lappe-Siefke, Corinna, Goebbels, Sandra, Radtke, Freddy, Aguet, Michel, Scherer, Steven S., Suter, Ueli, Nave, Klaus-Armin, Mantei, Ned
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174019/
https://www.ncbi.nlm.nih.gov/pubmed/12186854
http://dx.doi.org/10.1083/jcb.200202002
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author Genoud, Stéphane
Lappe-Siefke, Corinna
Goebbels, Sandra
Radtke, Freddy
Aguet, Michel
Scherer, Steven S.
Suter, Ueli
Nave, Klaus-Armin
Mantei, Ned
author_facet Genoud, Stéphane
Lappe-Siefke, Corinna
Goebbels, Sandra
Radtke, Freddy
Aguet, Michel
Scherer, Steven S.
Suter, Ueli
Nave, Klaus-Armin
Mantei, Ned
author_sort Genoud, Stéphane
collection PubMed
description We have selectively inhibited Notch1 signaling in oligodendrocyte precursors (OPCs) using the Cre/loxP system in transgenic mice to investigate the role of Notch1 in oligodendrocyte (OL) development and differentiation. Early development of OPCs appeared normal in the spinal cord. However, at embryonic day 17.5, premature OL differentiation was observed and ectopic immature OLs were present in the gray matter. At birth, OL apoptosis was strongly increased in Notch1 mutant animals. Premature OL differentiation was also observed in the cerebrum, indicating that Notch1 is required for the correct spatial and temporal regulation of OL differentiation in various regions of the central nervous system. These findings establish a widespread function of Notch1 in the late steps of mammalian OPC development in vivo.
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spelling pubmed-21740192008-05-01 Notch1 control of oligodendrocyte differentiation in the spinal cord Genoud, Stéphane Lappe-Siefke, Corinna Goebbels, Sandra Radtke, Freddy Aguet, Michel Scherer, Steven S. Suter, Ueli Nave, Klaus-Armin Mantei, Ned J Cell Biol Article We have selectively inhibited Notch1 signaling in oligodendrocyte precursors (OPCs) using the Cre/loxP system in transgenic mice to investigate the role of Notch1 in oligodendrocyte (OL) development and differentiation. Early development of OPCs appeared normal in the spinal cord. However, at embryonic day 17.5, premature OL differentiation was observed and ectopic immature OLs were present in the gray matter. At birth, OL apoptosis was strongly increased in Notch1 mutant animals. Premature OL differentiation was also observed in the cerebrum, indicating that Notch1 is required for the correct spatial and temporal regulation of OL differentiation in various regions of the central nervous system. These findings establish a widespread function of Notch1 in the late steps of mammalian OPC development in vivo. The Rockefeller University Press 2002-08-19 /pmc/articles/PMC2174019/ /pubmed/12186854 http://dx.doi.org/10.1083/jcb.200202002 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Genoud, Stéphane
Lappe-Siefke, Corinna
Goebbels, Sandra
Radtke, Freddy
Aguet, Michel
Scherer, Steven S.
Suter, Ueli
Nave, Klaus-Armin
Mantei, Ned
Notch1 control of oligodendrocyte differentiation in the spinal cord
title Notch1 control of oligodendrocyte differentiation in the spinal cord
title_full Notch1 control of oligodendrocyte differentiation in the spinal cord
title_fullStr Notch1 control of oligodendrocyte differentiation in the spinal cord
title_full_unstemmed Notch1 control of oligodendrocyte differentiation in the spinal cord
title_short Notch1 control of oligodendrocyte differentiation in the spinal cord
title_sort notch1 control of oligodendrocyte differentiation in the spinal cord
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174019/
https://www.ncbi.nlm.nih.gov/pubmed/12186854
http://dx.doi.org/10.1083/jcb.200202002
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