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Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle
Centrosome duplication is marked by discrete changes in centriole structure that occur in lockstep with cell cycle transitions. We show that mitotic regulators govern steps in centriole replication in Drosophila embryos. Cdc25(string), the expression of which initiates mitosis, is required for compl...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174235/ https://www.ncbi.nlm.nih.gov/pubmed/10613895 |
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author | Vidwans, Smruti J. Wong, Mei Lie O'Farrell, Patrick H. |
author_facet | Vidwans, Smruti J. Wong, Mei Lie O'Farrell, Patrick H. |
author_sort | Vidwans, Smruti J. |
collection | PubMed |
description | Centrosome duplication is marked by discrete changes in centriole structure that occur in lockstep with cell cycle transitions. We show that mitotic regulators govern steps in centriole replication in Drosophila embryos. Cdc25(string), the expression of which initiates mitosis, is required for completion of daughter centriole assembly. Cdc20(fizzy), which is required for the metaphase-anaphase transition, is required for timely disengagement of mother and daughter centrioles. Stabilization of mitotic cyclins, which prevents exit from mitosis, blocks assembly of new daughter centrioles. Common regulation of the nuclear and centrosome cycles by mitotic regulators may ensure precise duplication of the centrosome. |
format | Text |
id | pubmed-2174235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21742352008-05-01 Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle Vidwans, Smruti J. Wong, Mei Lie O'Farrell, Patrick H. J Cell Biol Brief Report Centrosome duplication is marked by discrete changes in centriole structure that occur in lockstep with cell cycle transitions. We show that mitotic regulators govern steps in centriole replication in Drosophila embryos. Cdc25(string), the expression of which initiates mitosis, is required for completion of daughter centriole assembly. Cdc20(fizzy), which is required for the metaphase-anaphase transition, is required for timely disengagement of mother and daughter centrioles. Stabilization of mitotic cyclins, which prevents exit from mitosis, blocks assembly of new daughter centrioles. Common regulation of the nuclear and centrosome cycles by mitotic regulators may ensure precise duplication of the centrosome. The Rockefeller University Press 1999-12-27 /pmc/articles/PMC2174235/ /pubmed/10613895 Text en © 1999 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Report Vidwans, Smruti J. Wong, Mei Lie O'Farrell, Patrick H. Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle |
title | Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle |
title_full | Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle |
title_fullStr | Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle |
title_full_unstemmed | Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle |
title_short | Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle |
title_sort | mitotic regulators govern progress through steps in the centrosome duplication cycle |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174235/ https://www.ncbi.nlm.nih.gov/pubmed/10613895 |
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