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A Novel Muscle-Specific β1 Integrin Binding Protein (Mibp) That Modulates Myogenic Differentiation
Myogenesis is regulated by cell adhesion receptors, including integrins of the β1 family. We report the identification of a novel muscle-specific β1 integrin binding protein (MIBP). MIBP binds to the membrane-proximal cytoplasmic region shared by β1A and β1D integrins, and the binding occurs in vivo...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174245/ https://www.ncbi.nlm.nih.gov/pubmed/10613898 |
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author | Li, Ji Mayne, Richard Wu, Chuanyue |
author_facet | Li, Ji Mayne, Richard Wu, Chuanyue |
author_sort | Li, Ji |
collection | PubMed |
description | Myogenesis is regulated by cell adhesion receptors, including integrins of the β1 family. We report the identification of a novel muscle-specific β1 integrin binding protein (MIBP). MIBP binds to the membrane-proximal cytoplasmic region shared by β1A and β1D integrins, and the binding occurs in vivo as well as in vitro. Furthermore, we show that MIBP is abundantly expressed by C2C12 myogenic cells before fusion, and the expression of MIBP is dramatically downregulated during subsequent differentiation. Finally, we show that overexpression of MIBP in C2C12 cells resulted in a suppression of fusion and terminal differentiation, suggesting that MIBP may play a key role in controlling the progression of muscle differentiation. |
format | Text |
id | pubmed-2174245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21742452008-05-01 A Novel Muscle-Specific β1 Integrin Binding Protein (Mibp) That Modulates Myogenic Differentiation Li, Ji Mayne, Richard Wu, Chuanyue J Cell Biol Brief Report Myogenesis is regulated by cell adhesion receptors, including integrins of the β1 family. We report the identification of a novel muscle-specific β1 integrin binding protein (MIBP). MIBP binds to the membrane-proximal cytoplasmic region shared by β1A and β1D integrins, and the binding occurs in vivo as well as in vitro. Furthermore, we show that MIBP is abundantly expressed by C2C12 myogenic cells before fusion, and the expression of MIBP is dramatically downregulated during subsequent differentiation. Finally, we show that overexpression of MIBP in C2C12 cells resulted in a suppression of fusion and terminal differentiation, suggesting that MIBP may play a key role in controlling the progression of muscle differentiation. The Rockefeller University Press 1999-12-27 /pmc/articles/PMC2174245/ /pubmed/10613898 Text en © 1999 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Report Li, Ji Mayne, Richard Wu, Chuanyue A Novel Muscle-Specific β1 Integrin Binding Protein (Mibp) That Modulates Myogenic Differentiation |
title | A Novel Muscle-Specific β1 Integrin Binding Protein (Mibp) That Modulates Myogenic Differentiation |
title_full | A Novel Muscle-Specific β1 Integrin Binding Protein (Mibp) That Modulates Myogenic Differentiation |
title_fullStr | A Novel Muscle-Specific β1 Integrin Binding Protein (Mibp) That Modulates Myogenic Differentiation |
title_full_unstemmed | A Novel Muscle-Specific β1 Integrin Binding Protein (Mibp) That Modulates Myogenic Differentiation |
title_short | A Novel Muscle-Specific β1 Integrin Binding Protein (Mibp) That Modulates Myogenic Differentiation |
title_sort | novel muscle-specific β1 integrin binding protein (mibp) that modulates myogenic differentiation |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174245/ https://www.ncbi.nlm.nih.gov/pubmed/10613898 |
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