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Caspase Recruitment Domain (Card-Dependent) Cytoplasmic Filaments Mediate Bcl10-Induced Nf-κb Activation
Mucosa-associated lymphoid tissue (MALT) lymphomas are associated with overexpression and constitutive activity of bcl10, a caspase recruitment domain (CARD)-containing protein that activates NF-κB. Here, we show that arrangement of overexpressed bcl10 protein in cytoplasmic filaments is essential f...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174297/ https://www.ncbi.nlm.nih.gov/pubmed/10725326 |
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author | Guiet, Chantal Vito, Pasquale |
author_facet | Guiet, Chantal Vito, Pasquale |
author_sort | Guiet, Chantal |
collection | PubMed |
description | Mucosa-associated lymphoid tissue (MALT) lymphomas are associated with overexpression and constitutive activity of bcl10, a caspase recruitment domain (CARD)-containing protein that activates NF-κB. Here, we show that arrangement of overexpressed bcl10 protein in cytoplasmic filaments is essential for recruitment of signal transducer molecules-involved NF-κB activation. We also show that cytoskeleton elements regulate bcl10 signaling. Thus, organized assemblage of proteins in ordered structures linked to the cytoskeleton network may represent a general mechanism for intracellular signaling. |
format | Text |
id | pubmed-2174297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21742972008-05-01 Caspase Recruitment Domain (Card-Dependent) Cytoplasmic Filaments Mediate Bcl10-Induced Nf-κb Activation Guiet, Chantal Vito, Pasquale J Cell Biol Brief Report Mucosa-associated lymphoid tissue (MALT) lymphomas are associated with overexpression and constitutive activity of bcl10, a caspase recruitment domain (CARD)-containing protein that activates NF-κB. Here, we show that arrangement of overexpressed bcl10 protein in cytoplasmic filaments is essential for recruitment of signal transducer molecules-involved NF-κB activation. We also show that cytoskeleton elements regulate bcl10 signaling. Thus, organized assemblage of proteins in ordered structures linked to the cytoskeleton network may represent a general mechanism for intracellular signaling. The Rockefeller University Press 2000-03-20 /pmc/articles/PMC2174297/ /pubmed/10725326 Text en © 2000 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Report Guiet, Chantal Vito, Pasquale Caspase Recruitment Domain (Card-Dependent) Cytoplasmic Filaments Mediate Bcl10-Induced Nf-κb Activation |
title | Caspase Recruitment Domain (Card-Dependent) Cytoplasmic Filaments Mediate Bcl10-Induced Nf-κb Activation |
title_full | Caspase Recruitment Domain (Card-Dependent) Cytoplasmic Filaments Mediate Bcl10-Induced Nf-κb Activation |
title_fullStr | Caspase Recruitment Domain (Card-Dependent) Cytoplasmic Filaments Mediate Bcl10-Induced Nf-κb Activation |
title_full_unstemmed | Caspase Recruitment Domain (Card-Dependent) Cytoplasmic Filaments Mediate Bcl10-Induced Nf-κb Activation |
title_short | Caspase Recruitment Domain (Card-Dependent) Cytoplasmic Filaments Mediate Bcl10-Induced Nf-κb Activation |
title_sort | caspase recruitment domain (card-dependent) cytoplasmic filaments mediate bcl10-induced nf-κb activation |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174297/ https://www.ncbi.nlm.nih.gov/pubmed/10725326 |
work_keys_str_mv | AT guietchantal caspaserecruitmentdomaincarddependentcytoplasmicfilamentsmediatebcl10inducednfkbactivation AT vitopasquale caspaserecruitmentdomaincarddependentcytoplasmicfilamentsmediatebcl10inducednfkbactivation |