β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2

Recently, a requirement for β-arrestin–mediated endocytosis in the activation of extracellular signal–regulated kinases 1 and 2 (ERK1/2) by several G protein–coupled receptors (GPCRs) has been proposed. However, the importance of this requirement for function of ERK1/2 is unknown. We report that ago...

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Detalles Bibliográficos
Autores principales: DeFea, K.A., Zalevsky, J., Thoma, M.S., Déry, O., Mullins, R.D., Bunnett, N.W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174299/
https://www.ncbi.nlm.nih.gov/pubmed/10725339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174299/
https://www.ncbi.nlm.nih.gov/pubmed/10725339

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