Cargando…

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

Phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α) on serine 51 integrates general translation repression with activation of stress-inducible genes such as ATF4, CHOP, and BiP in the unfolded protein response. We sought to identify new genes active in this phospho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Novoa, Isabel, Zeng, Huiqing, Harding, Heather P., Ron, David
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2001
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174339/ https://www.ncbi.nlm.nih.gov/pubmed/11381086

Ejemplares similares

GADD34-mediated dephosphorylation of eIF2α facilitates pseudorabies virus replication by maintaining de novo protein synthesis
por: Zhu, Ting, et al.
Publicado: (2021)

Inhibition of eIF2α dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells
por: Teng, Y, et al.
Publicado: (2014)

EBNA3C interacts with Gadd34 and counteracts the unfolded protein response
por: Garrido, Jose L, et al.
Publicado: (2009)

GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor
por: Shi, Weibin, et al.
Publicado: (2004)

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
por: Crespillo-Casado, Ana, et al.
Publicado: (2017)

Inhibition of eIF2α dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis
por: Sequeira, Sharon J, et al.
Publicado: (2009)

Inhibition of eIF2α Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury
por: Tang, Yong-Jing, et al.
Publicado: (2020)

Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant
por: Eytan, Karin, et al.
Publicado: (2022)

Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage
por: Matsuoka, Masato, et al.
Publicado: (2015)

ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α
por: Lee, Duckgue, et al.
Publicado: (2019)

GADD34 is a modulator of autophagy during starvation
por: Gambardella, Gennaro, et al.
Publicado: (2020)

Inhibition of eIF2α dephosphorylation accelerates pterostilbene-induced cell death in human hepatocellular carcinoma cells in an ER stress and autophagy-dependent manner
por: Yu, Chen-Lin, et al.
Publicado: (2019)

GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy
por: Ito, Sachiko, et al.
Publicado: (2015)

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B
por: Zyryanova, Alisa F., et al.
Publicado: (2021)

LINP1 represses unfolded protein response by directly inhibiting eIF2α phosphorylation to promote cutaneous squamous cell carcinoma
por: Liang, Xiaoting, et al.
Publicado: (2023)

C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α
por: Zheng, Wenzhong, et al.
Publicado: (2022)

Inhibition of EIF2α Dephosphorylation Decreases Cell Viability and Synergizes with Standard-of-Care Chemotherapeutics in Head and Neck Squamous Cell Carcinoma
por: Cyran, Anna M., et al.
Publicado: (2023)

Negative Regulation of GADD34 on Myofibroblasts during Cutaneous Wound Healing
por: Liu, Lintao, et al.
Publicado: (2014)

Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway
por: Tang, Yan, et al.
Publicado: (2017)

Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation
por: Bogorad, Andrew M., et al.
Publicado: (2017)

eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B
por: Kim, Eunah, et al.
Publicado: (2018)

HTLV-1 HBZ activates mTOR signaling pathway via inhibition of GADD34
por: Mukai, Risa, et al.
Publicado: (2011)

Rapamycin-Induced Feedback Activation of eIF4E-EIF4A Dependent mRNA Translation in Pancreatic Cancer
por: Nguyen, Trang Uyen, et al.
Publicado: (2023)

Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2α and inhibiting activation of pro-apoptotic CHOP
por: Barber, Claire, et al.
Publicado: (2017)

DUSP5 functions as a feedback regulator of TNFα-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes
por: Habibian, Justine S., et al.
Publicado: (2017)

Inhibition of a constitutive translation initiation factor 2α phosphatase, CReP, promotes survival of stressed cells
por: Jousse, Céline, et al.
Publicado: (2003)

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation
por: Rathore, Abhay P S, et al.
Publicado: (2013)

PERK/eIF2α signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1α translation
por: Ivanova, Iglika G, et al.
Publicado: (2018)

Enhancement of the Acrolein-Induced Production of Reactive Oxygen Species and Lung Injury by GADD34
por: Sun, Yang, et al.
Publicado: (2015)

GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice
por: Saltykova, Irina V., et al.
Publicado: (2022)

GADD34 activates p53 and may have utility as a marker of atherosclerosis
por: Tomiyoshi, Go, et al.
Publicado: (2023)

Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice
por: Tanaka, Yuriko, et al.
Publicado: (2015)

Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives
por: Sesma, Ane, et al.
Publicado: (2017)

Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation
por: Gao, Ming, et al.
Publicado: (2013)

Synergistic activation of eIF4A by eIF4B and eIF4G
por: Nielsen, Klaus H., et al.
Publicado: (2011)

Stress-induced inhibition of translation independently of eIF2α phosphorylation
por: Knutsen, Jon Halvor Jonsrud, et al.
Publicado: (2015)

Structural basis for the inhibition of translation through eIF2α phosphorylation
por: Gordiyenko, Yuliya, et al.
Publicado: (2019)

Roles of yeast eIF2α and eIF2β subunits in the binding of the initiator methionyl-tRNA
por: Naveau, Marie, et al.
Publicado: (2013)

Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress–induced cell death during the unfolded protein response
por: Hiramatsu, Nobuhiko, et al.
Publicado: (2014)

Expression of Human Mutant Preproinsulins Induced Unfolded Protein Response, Gadd45 Expression, JAK-STAT Activation, and Growth Inhibition in Drosophila
por: Yamazoe, Tatsuki, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qq4v4i3or3hncdrfelndo9aetm