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Alternatively spliced isoforms encoded by cadherin genes from C. elegansgenome

Cadherins are calcium-dependent, homophilic, cell-cell adhesion receptors that regulate morphogenesis, pattern formation and cell migration. The C. elegans Genome Sequencing Consortium has reported 12 genes from C. elegansgenome encoding members of the cadherin superfamily. Alternative splicing of e...

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Detalles Bibliográficos
Autores principales: Kashyap, Luv, Tabish, Mohammad
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics Publishing Group 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174417/
https://www.ncbi.nlm.nih.gov/pubmed/18188420
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author Kashyap, Luv
Tabish, Mohammad
author_facet Kashyap, Luv
Tabish, Mohammad
author_sort Kashyap, Luv
collection PubMed
description Cadherins are calcium-dependent, homophilic, cell-cell adhesion receptors that regulate morphogenesis, pattern formation and cell migration. The C. elegans Genome Sequencing Consortium has reported 12 genes from C. elegansgenome encoding members of the cadherin superfamily. Alternative splicing of eukaryotic pre-mRNAs is a mechanism for generating potentially many transcript isoforms from a single gene. Here, using a combination of various gene or exon finding programmes and several other bioinformatics tools followed by experimental validation using RT-PCR, we have studied alternative splicing pattern in the cadherin encoding genes from C. elegansgenome. We have predicted that 7 of the 12 genes encoding the cadherin superfamily undergo extensive alternative splicing and encode for 12 new unreported alternatively spliced transcripts. Most of the alternatively spliced exons were found to be present at the 5' end of genes. These new previously un-detected spliced variants in C. eleganscadherin superfamily of genes could play vital roles in explaining the way cadherins act to control the processes like cell adhesion and morphogenesis.
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spelling pubmed-21744172008-01-10 Alternatively spliced isoforms encoded by cadherin genes from C. elegansgenome Kashyap, Luv Tabish, Mohammad Bioinformation Hypothesis Cadherins are calcium-dependent, homophilic, cell-cell adhesion receptors that regulate morphogenesis, pattern formation and cell migration. The C. elegans Genome Sequencing Consortium has reported 12 genes from C. elegansgenome encoding members of the cadherin superfamily. Alternative splicing of eukaryotic pre-mRNAs is a mechanism for generating potentially many transcript isoforms from a single gene. Here, using a combination of various gene or exon finding programmes and several other bioinformatics tools followed by experimental validation using RT-PCR, we have studied alternative splicing pattern in the cadherin encoding genes from C. elegansgenome. We have predicted that 7 of the 12 genes encoding the cadherin superfamily undergo extensive alternative splicing and encode for 12 new unreported alternatively spliced transcripts. Most of the alternatively spliced exons were found to be present at the 5' end of genes. These new previously un-detected spliced variants in C. eleganscadherin superfamily of genes could play vital roles in explaining the way cadherins act to control the processes like cell adhesion and morphogenesis. Biomedical Informatics Publishing Group 2007-09-24 /pmc/articles/PMC2174417/ /pubmed/18188420 Text en © 2007 Biomedical Informatics Publishing Group This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Kashyap, Luv
Tabish, Mohammad
Alternatively spliced isoforms encoded by cadherin genes from C. elegansgenome
title Alternatively spliced isoforms encoded by cadherin genes from C. elegansgenome
title_full Alternatively spliced isoforms encoded by cadherin genes from C. elegansgenome
title_fullStr Alternatively spliced isoforms encoded by cadherin genes from C. elegansgenome
title_full_unstemmed Alternatively spliced isoforms encoded by cadherin genes from C. elegansgenome
title_short Alternatively spliced isoforms encoded by cadherin genes from C. elegansgenome
title_sort alternatively spliced isoforms encoded by cadherin genes from c. elegansgenome
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174417/
https://www.ncbi.nlm.nih.gov/pubmed/18188420
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