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Brucella bacteremia in patients with acute leukemia: a case series
BACKGROUND: Brucellosis may cause serious infections in healthy individuals living in countries that are endemic for the infection. However, reports of brucella infections in immunocompromised hosts are relatively rare. CASE PRESENTATIONS: Reported here are two patients with acute leukemia who devel...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174500/ https://www.ncbi.nlm.nih.gov/pubmed/18036218 http://dx.doi.org/10.1186/1752-1947-1-144 |
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author | Al-Anazi, Khalid Ahmed Al-Jasser, Asma Marzouq |
author_facet | Al-Anazi, Khalid Ahmed Al-Jasser, Asma Marzouq |
author_sort | Al-Anazi, Khalid Ahmed |
collection | PubMed |
description | BACKGROUND: Brucellosis may cause serious infections in healthy individuals living in countries that are endemic for the infection. However, reports of brucella infections in immunocompromised hosts are relatively rare. CASE PRESENTATIONS: Reported here are two patients with acute leukemia who developed Brucella melitensis bacteremia during their follow up at the Armed Forces Hospital in Riyadh. The first patient developed B. melitensis bacteremia during the transformation of his myelodysplasia into acute myeloid leukemia. The second patient developed B. melitensis bacteremia while his acute lymphoblastic leukemia was under control. Interestingly, he presented with acute cholecystitis during the brucella sepsis. Both brucella infections were associated with a marked reduction in the hematological parameters in addition to other complications. The bacteremic episodes were successfully treated with netilmicin, doxycycline and ciprofloxacin. CONCLUSION: Brucellosis can cause systemic infections, complicated bacteremia and serious morbidity in patients with acute leukemia living in endemic areas. These infections may occur at the presentation of the leukemia or even when the leukemia is in remission. Nevertheless, the early diagnosis of brucellosis and the administration of appropriate antimicrobial therapy for sufficient duration usually improves the outcome in these immunocompromised patients. |
format | Text |
id | pubmed-2174500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-21745002008-01-04 Brucella bacteremia in patients with acute leukemia: a case series Al-Anazi, Khalid Ahmed Al-Jasser, Asma Marzouq J Med Case Reports Case Report BACKGROUND: Brucellosis may cause serious infections in healthy individuals living in countries that are endemic for the infection. However, reports of brucella infections in immunocompromised hosts are relatively rare. CASE PRESENTATIONS: Reported here are two patients with acute leukemia who developed Brucella melitensis bacteremia during their follow up at the Armed Forces Hospital in Riyadh. The first patient developed B. melitensis bacteremia during the transformation of his myelodysplasia into acute myeloid leukemia. The second patient developed B. melitensis bacteremia while his acute lymphoblastic leukemia was under control. Interestingly, he presented with acute cholecystitis during the brucella sepsis. Both brucella infections were associated with a marked reduction in the hematological parameters in addition to other complications. The bacteremic episodes were successfully treated with netilmicin, doxycycline and ciprofloxacin. CONCLUSION: Brucellosis can cause systemic infections, complicated bacteremia and serious morbidity in patients with acute leukemia living in endemic areas. These infections may occur at the presentation of the leukemia or even when the leukemia is in remission. Nevertheless, the early diagnosis of brucellosis and the administration of appropriate antimicrobial therapy for sufficient duration usually improves the outcome in these immunocompromised patients. BioMed Central 2007-11-23 /pmc/articles/PMC2174500/ /pubmed/18036218 http://dx.doi.org/10.1186/1752-1947-1-144 Text en Copyright © 2007 Al-Anazi and Al-Jasser; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Al-Anazi, Khalid Ahmed Al-Jasser, Asma Marzouq Brucella bacteremia in patients with acute leukemia: a case series |
title | Brucella bacteremia in patients with acute leukemia: a case series |
title_full | Brucella bacteremia in patients with acute leukemia: a case series |
title_fullStr | Brucella bacteremia in patients with acute leukemia: a case series |
title_full_unstemmed | Brucella bacteremia in patients with acute leukemia: a case series |
title_short | Brucella bacteremia in patients with acute leukemia: a case series |
title_sort | brucella bacteremia in patients with acute leukemia: a case series |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174500/ https://www.ncbi.nlm.nih.gov/pubmed/18036218 http://dx.doi.org/10.1186/1752-1947-1-144 |
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