Reduced Loading of Intracellular Ca(2+) Stores and Downregulation of Capacitative Ca(2+)Influx in Bcl-2–Overexpressing Cells

The mechanism of action of the oncogene bcl-2, a key regulator of the apoptotic process, is still debated. We have employed organelle-targeted chimeras of the Ca(2+)-sensitive photoprotein, aequorin, to investigate in detail the effect of Bcl-2 overexpression on intracellular Ca(2+) homeostasis. In...

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Detalles Bibliográficos
Autores principales: Pinton, Paolo, Ferrari, Davide, Magalhães, Paulo, Schulze-Osthoff, Klaus, Di Virgilio, Francesco, Pozzan, Tullio, Rizzuto, Rosario
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174537/
https://www.ncbi.nlm.nih.gov/pubmed/10704437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174537/
https://www.ncbi.nlm.nih.gov/pubmed/10704437

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