Cargando…

Reduced Loading of Intracellular Ca(2+) Stores and Downregulation of Capacitative Ca(2+)Influx in Bcl-2–Overexpressing Cells

The mechanism of action of the oncogene bcl-2, a key regulator of the apoptotic process, is still debated. We have employed organelle-targeted chimeras of the Ca(2+)-sensitive photoprotein, aequorin, to investigate in detail the effect of Bcl-2 overexpression on intracellular Ca(2+) homeostasis. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pinton, Paolo, Ferrari, Davide, Magalhães, Paulo, Schulze-Osthoff, Klaus, Di Virgilio, Francesco, Pozzan, Tullio, Rizzuto, Rosario
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2000
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174537/ https://www.ncbi.nlm.nih.gov/pubmed/10704437

Ejemplares similares

Presenilin-2 dampens intracellular Ca(2+) stores by increasing Ca(2+) leakage and reducing Ca(2+) uptake
por: Brunello, Lucia, et al.
Publicado: (2009)

Capacitative Ca(2+) Entry Is Closely Linked to the Filling State of Internal Ca(2+) Stores: A Study Using Simultaneous Measurements of I(CRAC) and Intraluminal [Ca(2+)]
por: Hofer, Aldebaran M., et al.
Publicado: (1998)

Dense core secretory vesicles revealed as a dynamic Ca(2+) store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera
por: Mitchell, Kathryn J., et al.
Publicado: (2001)

Activation of different Cl currents in Xenopus oocytes by Ca liberated from stores and by capacitative Ca influx
Publicado: (1996)

Intracellular Ca(2+) Stores and Ca(2+) Influx Are Both Required for BDNF to Rapidly Increase Quantal Vesicular Transmitter Release
por: Amaral, Michelle D., et al.
Publicado: (2012)

Ca(2+) Homeostasis in the Endoplasmic Reticulum: Coexistence of High and Low [Ca(2+)] Subcompartments in Intact HeLa Cells
por: Montero, Mayte, et al.
Publicado: (1997)

The Heterogeneity of ER Ca(2+) Stores Has a Key Role in Nonmuscle Cell Signaling and Function
por: Meldolesi, Jacopo, et al.
Publicado: (1998)

Termination of cAMP signals by Ca(2+) and Gα(i) via extracellular Ca(2+) sensors: a link to intracellular Ca(2+) oscillations
por: Gerbino, Andrea, et al.
Publicado: (2005)

Ca2+ influx pathways mediated by swelling or stores depletion in mouse thymocytes
Publicado: (1995)

The BSA-induced Ca(2+) influx during sperm capacitation is CATSPER channel-dependent
por: Xia, Jingsheng, et al.
Publicado: (2009)

Ca(2+) influx and the store-operated Ca(2+) entry pathway undergo regulation during mouse oocyte maturation
por: Cheon, Banyoon, et al.
Publicado: (2013)

STIMulating Ca(2+) influx
por: LeBrasseur, Nicole
Publicado: (2006)

Blockage of Store-Operated Ca(2+) Influx by Synta66 is Mediated by Direct Inhibition of the Ca(2+) Selective Orai1 Pore
por: Waldherr, Linda, et al.
Publicado: (2020)

Ca(2+) Influx in T Cells: How Many Ca(2+) Channels?
por: Feske, Stefan
Publicado: (2013)

Microdomain Ca(2+) Activation during Exocytosis in Paramecium Cells. Superposition of Local Subplasmalemmal Calcium Store Activation by Local Ca(2+) Influx
por: Erxleben, Christian, et al.
Publicado: (1997)

In vivo monitoring of Ca(2+) uptake into mitochondria of mouse skeletal muscle during contraction
por: Rudolf, Rüdiger, et al.
Publicado: (2004)

Ca(2+) Homeostasis in the Agonist-sensitive Internal Store: Functional Interactions Between Mitochondria and the ER Measured In Situ in Intact Cells
por: Landolfi, Barbara, et al.
Publicado: (1998)

Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes
Publicado: (1994)

Direct in vivo monitoring of sarcoplasmic reticulum Ca(2+) and cytosolic cAMP dynamics in mouse skeletal muscle
por: Rudolf, Rüdiger, et al.
Publicado: (2006)

The relationship between depletion of intracellular Ca2+ stores and activation of Ca2+ current by muscarinic receptors in neuroblastoma cells
Publicado: (1995)

Purinergic-mediated Ca(2+) influx in Dictyostelium discoideum
por: Ludlow, Melanie J., et al.
Publicado: (2008)

Inhibiting the Ca(2+) Influx Induced by Human CSF
por: Drews, Anna, et al.
Publicado: (2017)

Citrus bergamia Risso Elevates Intracellular Ca(2+) in Human Vascular Endothelial Cells due to Release of Ca(2+) from Primary Intracellular Stores
por: Kang, Purum, et al.
Publicado: (2013)

Acute atrial arrhythmogenesis in murine hearts following enhanced extracellular Ca(2+) entry depends on intracellular Ca(2+) stores
por: Zhang, Y, et al.
Publicado: (2010)

Inhibitors of Bcl-2 protein family deplete ER Ca(2+) stores in pancreatic acinar cells
por: Gerasimenko, Julia, et al.
Publicado: (2010)

Bcl-2 regulates store-operated Ca(2+) entry to modulate ER stress-induced apoptosis
por: Chiu, Wen-Tai, et al.
Publicado: (2018)

Long-term modulation of mitochondrial Ca(2+) signals by protein kinase C isozymes
por: Pinton, Paolo, et al.
Publicado: (2004)

Enhanced store-operated Ca(2+) influx and ORAI1 expression in ventricular fibroblasts from human failing heart
por: Ross, Gracious R., et al.
Publicado: (2017)

Increased Ca(2+) influx through Ca(V)1.2 drives aortic valve calcification
por: Matsui, Maiko, et al.
Publicado: (2022)

Ca2+ influx activated by low pH in Chlamydomonas
Publicado: (1996)

Astrocyte Ca(2+) Influx Negatively Regulates Neuronal Activity
por: Zhang, Yao V., et al.
Publicado: (2017)

Orchestrating Ca(2+) influx through Ca(V)1.2 and Ca(V)3.x channels in human cerebral arteries
por: Collier, Daniel M., et al.
Publicado: (2015)

The Trans Golgi Region is a Labile Intracellular Ca(2+) Store Sensitive to Emetine
por: Gallegos-Gómez, Martín-Leonardo, et al.
Publicado: (2018)

The oscillation of intracellular Ca(2+) influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium
por: Ihara, Tatsuya, et al.
Publicado: (2018)

A [Na+]o-independent, pHo-dependent mechanism for reduction of intracellular [Ca2+] after influx through Ca2+ channels in mouse pituitary cells
Publicado: (1991)

Characterization of the ER-Targeted Low Affinity Ca(2+) Probe D4ER
por: Greotti, Elisa, et al.
Publicado: (2016)

The contractile vacuole in Ca(2+)-regulation in Dictyostelium: its essential function for cAMP-induced Ca(2+)-influx
por: Malchow, Dieter, et al.
Publicado: (2006)

Ca(2+) influx–independent synaptic potentiation mediated by mitochondrial Na(+)-Ca(2+) exchanger and protein kinase C
por: Yang, Feng, et al.
Publicado: (2003)

Na(+)-induced Ca(2+) influx through reverse mode of Na(+)-Ca(2+) exchanger in mouse ventricular cardiomyocyte
por: Yan, Zhen-Yu, et al.
Publicado: (2015)

Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca(2+) release and Ca(2+) influx
por: Kilpatrick, Bethan S., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rn6kpcb8otav4vu22l8paoi886