P(0) Glycoprotein Overexpression Causes Congenital Hypomyelination of Peripheral Nerves

We show that normal peripheral nerve myelination depends on strict dosage of the most abundantly expressed myelin gene, myelin protein zero (Mpz). Transgenic mice containing extra copies of Mpz manifested a dose-dependent, dysmyelinating neuropathy, ranging from transient perinatal hypomyelination t...

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Detalles Bibliográficos
Autores principales: Wrabetz, Lawrence, Feltri, Maria Laura, Quattrini, Angelo, Imperiale, Daniele, Previtali, Stefano, D'Antonio, Maurizio, Martini, Rudolf, Yin, Xinghua, Trapp, Bruce D., Zhou, Lei, Chiu, Shing-Yan, Messing, Albee
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174542/
https://www.ncbi.nlm.nih.gov/pubmed/10704451

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