Regulation of Hmg-Coa Reductase Degradation Requires the P-Type Atpase Cod1p/Spf1p

The integral ER membrane protein HMG-CoA reductase (HMGR) is a key enzyme of the mevalonate pathway from which sterols and other essential molecules are produced. HMGR degradation occurs in the ER and is regulated by mevalonate-derived signals. Little is known about the mechanisms responsible for re...

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Detalles Bibliográficos
Autores principales: Cronin, Stephen R., Khoury, Afif, Ferry, Dana K., Hampton, Randolph Y.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174543/
https://www.ncbi.nlm.nih.gov/pubmed/10704442

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