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The Molecular Mechanisms of OPA1-Mediated Optic Atrophy in Drosophila Model and Prospects for Antioxidant Treatment

Mutations in optic atrophy 1 (OPA1), a nuclear gene encoding a mitochondrial protein, is the most common cause for autosomal dominant optic atrophy (DOA). The condition is characterized by gradual loss of vision, color vision defects, and temporal optic pallor. To understand the molecular mechanism...

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Detalles Bibliográficos
Autores principales:	Yarosh, Will, Monserrate, Jessica, Tong, James Jiayuan, Tse, Stephanie, Le, Phung Khanh, Nguyen, Kimberly, Brachmann, Carrie B, Wallace, Douglas C, Huang, Taosheng
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174975/ https://www.ncbi.nlm.nih.gov/pubmed/18193945 http://dx.doi.org/10.1371/journal.pgen.0040006

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