Activated ras Prevents Downregulation of Bcl-X(L) Triggered by Detachment from the Extracellular Matrix: A Mechanism of ras-Induced Resistance to Anoikis in Intestinal Epithelial Cells

Detachment of epithelial cells from the extracellular matrix (ECM) results in a form of apoptosis often referred to as anoikis. Transformation of intestinal epithelial cells by oncogenic ras leads to resistance to anoikis, and this resistance is required for the full manifestation of the malignant p...

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Detalles Bibliográficos
Autores principales: Rosen, Kirill, Rak, Janusz, Leung, Thomas, Dean, Nicholas M., Kerbel, Robert S., Filmus, Jorge
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175156/
https://www.ncbi.nlm.nih.gov/pubmed/10769035

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