Cargando…

Two Cell Adhesion Molecules, Nectin and Cadherin, Interact through Their Cytoplasmic Domain–Associated Proteins

We have found a new cell–cell adhesion system at cadherin-based cell–cell adherens junctions (AJs) consisting of at least nectin and l-afadin. Nectin is a Ca(2+)-independent homophilic immunoglobulin-like adhesion molecule, and l-afadin is an actin filament-binding protein that connects the cytoplas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tachibana, Kouichi, Nakanishi, Hiroyuki, Mandai, Kenji, Ozaki, Kumi, Ikeda, Wataru, Yamamoto, Yasunori, Nagafuchi, Akira, Tsukita, Shoichiro, Takai, Yoshimi
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2000
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175253/ https://www.ncbi.nlm.nih.gov/pubmed/10974003

Ejemplares similares

Nectin: an adhesion molecule involved in formation of synapses
por: Mizoguchi, Akira, et al.
Publicado: (2002)

Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein
por: Takahashi, Kenichi, et al.
Publicado: (1999)

Functional Domains of α-Catenin Required for the Strong State of Cadherin-based Cell Adhesion
por: Imamura, Yuzo, et al.
Publicado: (1999)

Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments
por: Itoh, Masahiko, et al.
Publicado: (1997)

Cytoplasmic Regulation of the Movement of E-Cadherin on the Free Cell Surface as Studied by Optical Tweezers and Single Particle Tracking: Corralling and Tethering by the Membrane Skeleton
por: Sako, Yasushi, et al.
Publicado: (1998)

Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery
por: Togashi, Hideru, et al.
Publicado: (2006)

Afadin: A Novel Actin Filament–binding Protein with One PDZ Domain Localized at Cadherin-based Cell-to-Cell Adherens Junction
por: Mandai, Kenji, et al.
Publicado: (1997)

Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology
por: OGITA, Hisakazu, et al.
Publicado: (2010)

Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium
por: Katsunuma, Sayaka, et al.
Publicado: (2016)

Refolding, crystallization and preliminary X-ray crystallographic study of the whole extracellular regions of nectins
por: Narita, Hirotaka, et al.
Publicado: (2011)

Tracing the evolution of nectin and nectin-like cell adhesion molecules
por: Duraivelan, Kheerthana, et al.
Publicado: (2020)

Inhibition of cell movement and proliferation by cell–cell contact-induced interaction of Necl-5 with nectin-3
por: Fujito, Tsutomu, et al.
Publicado: (2005)

Correction: Inhibition of cell movement and proliferation by cell–cell contact-induced interaction of Necl-5 with nectin-3
por: Fujito, Tsutomu, et al.
Publicado: (2020)

Rapid Suppression of Activated Rac1 by Cadherins and Nectins during De Novo Cell-Cell Adhesion
por: Kitt, Khameeka N., et al.
Publicado: (2011)

Nectin-like molecule-4/cell adhesion molecule 4 inhibits the ligand-induced dimerization of ErbB3 with ErbB2
por: Mizutani, Kiyohito, et al.
Publicado: (2017)

The Adherens Junction: A Mosaic of Cadherin and Nectin Clusters Bundled by Actin Filaments
por: Indra, Indrajyoti, et al.
Publicado: (2013)

Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG
por: Fukuhara, Tatsuro, et al.
Publicado: (2004)

Frequent Loss of α Catenin Expression in Scirrhous Carcinomas with Scattered Cell Growth
por: Ochiai, Atsushi, et al.
Publicado: (1994)

Nectin ectodomain structures reveal a canonical adhesive interface
por: Harrison, Oliver J., et al.
Publicado: (2012)

Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target?
por: Tanaka, Yuka, et al.
Publicado: (2021)

LI-Cadherin–mediated Cell–Cell Adhesion Does Not Require Cytoplasmic Interactions
por: Kreft, Bertolt, et al.
Publicado: (1997)

Nectin-4 cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, enhancing their activation and DNA synthesis
por: Kedashiro, Shin, et al.
Publicado: (2019)

Afadin: A Key Molecule Essential for Structural Organization of Cell–Cell Junctions of Polarized Epithelia during Embryogenesis
por: Ikeda, Wataru, et al.
Publicado: (1999)

Ponsin/SH3P12: An l-Afadin– and Vinculin-binding Protein Localized at Cell–Cell and Cell–Matrix Adherens Junctions
por: Mandai, Kenji, et al.
Publicado: (1999)

Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling
por: Yano, Tomoki, et al.
Publicado: (2011)

Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions
por: Itoh, Masahiko, et al.
Publicado: (2001)

The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice
por: Barron, Martin J., et al.
Publicado: (2008)

Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis
por: Izumi, Hideki, et al.
Publicado: (2015)

p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis
por: Mollo, Maria Rosaria, et al.
Publicado: (2015)

Diagnostic and Prognostic Roles of Urine Nectin-2 and Nectin-4 in Human Bladder Cancer
por: Miyake, Makito, et al.
Publicado: (2023)

Genetic variants in NECTIN4 encoding an adhesion molecule are associated with continued opioid use
por: Fang, Chiu-Ping, et al.
Publicado: (2020)

The Membrane-proximal Region of the E-Cadherin Cytoplasmic Domain Prevents Dimerization and Negatively Regulates Adhesion Activity
por: Ozawa, Masayuki, et al.
Publicado: (1998)

Con-nectin axons and dendrites
por: Beaudoin, Gerard M.J.
Publicado: (2006)

Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent T47D cell proliferation
por: Kedashiro, Shin, et al.
Publicado: (2021)

Neurabin: A Novel Neural Tissue–specific Actin Filament–binding Protein Involved in Neurite Formation
por: Nakanishi, Hiroyuki, et al.
Publicado: (1997)

Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2
por: Yonemura, Shigenobu, et al.
Publicado: (1998)

Nectin-3 (CD113) Interacts with Nectin-2 (CD112) to Promote Lymphocyte Transendothelial Migration
por: Devilard, Elisabeth, et al.
Publicado: (2013)

The Systematic Landscape of Nectin Family and Nectin-Like Molecules: Functions and Prognostic Value in Low Grade Glioma
por: Han, Yunhe, et al.
Publicado: (2021)

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120(ctn)
por: Yap, Alpha S., et al.
Publicado: (1998)

Expression of nectin-4 in prostate cancer
por: Ordu, Melike, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rkap8tl2o11fo8un47f2285hp0