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Cross-Talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis
Calpains and caspases are two cysteine protease families that play important roles in regulating pathological cell death. Here, we report that m-calpain may be responsible for cleaving procaspase-12, a caspase localized in the ER, to generate active caspase-12. In addition, calpain may be responsibl...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175271/ https://www.ncbi.nlm.nih.gov/pubmed/10953012 |
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author | Nakagawa, Toshiyuki Yuan, Junying |
author_facet | Nakagawa, Toshiyuki Yuan, Junying |
author_sort | Nakagawa, Toshiyuki |
collection | PubMed |
description | Calpains and caspases are two cysteine protease families that play important roles in regulating pathological cell death. Here, we report that m-calpain may be responsible for cleaving procaspase-12, a caspase localized in the ER, to generate active caspase-12. In addition, calpain may be responsible for cleaving the loop region in Bcl-xL and, therefore, turning an antiapoptotic molecule into a proapoptotic molecule. We propose that disturbance to intracellular calcium storage as a result of ischemic injury or amyloid β peptide cytotoxicity may induce apoptosis through calpain- mediated caspase-12 activation and Bcl-xL inactivation. These data suggest a novel apoptotic pathway involving calcium-mediated calpain activation and cross-talks between calpain and caspase families. |
format | Text |
id | pubmed-2175271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21752712008-05-01 Cross-Talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis Nakagawa, Toshiyuki Yuan, Junying J Cell Biol Report Calpains and caspases are two cysteine protease families that play important roles in regulating pathological cell death. Here, we report that m-calpain may be responsible for cleaving procaspase-12, a caspase localized in the ER, to generate active caspase-12. In addition, calpain may be responsible for cleaving the loop region in Bcl-xL and, therefore, turning an antiapoptotic molecule into a proapoptotic molecule. We propose that disturbance to intracellular calcium storage as a result of ischemic injury or amyloid β peptide cytotoxicity may induce apoptosis through calpain- mediated caspase-12 activation and Bcl-xL inactivation. These data suggest a novel apoptotic pathway involving calcium-mediated calpain activation and cross-talks between calpain and caspase families. The Rockefeller University Press 2000-08-21 /pmc/articles/PMC2175271/ /pubmed/10953012 Text en © 2000 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Report Nakagawa, Toshiyuki Yuan, Junying Cross-Talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis |
title | Cross-Talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis |
title_full | Cross-Talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis |
title_fullStr | Cross-Talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis |
title_full_unstemmed | Cross-Talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis |
title_short | Cross-Talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis |
title_sort | cross-talk between two cysteine protease families: activation of caspase-12 by calpain in apoptosis |
topic | Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175271/ https://www.ncbi.nlm.nih.gov/pubmed/10953012 |
work_keys_str_mv | AT nakagawatoshiyuki crosstalkbetweentwocysteineproteasefamiliesactivationofcaspase12bycalpaininapoptosis AT yuanjunying crosstalkbetweentwocysteineproteasefamiliesactivationofcaspase12bycalpaininapoptosis |