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Cross-Talk between Two Cysteine Protease Families: Activation of Caspase-12 by Calpain in Apoptosis

Calpains and caspases are two cysteine protease families that play important roles in regulating pathological cell death. Here, we report that m-calpain may be responsible for cleaving procaspase-12, a caspase localized in the ER, to generate active caspase-12. In addition, calpain may be responsibl...

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Detalles Bibliográficos
Autores principales: Nakagawa, Toshiyuki, Yuan, Junying
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175271/
https://www.ncbi.nlm.nih.gov/pubmed/10953012