Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts

ROCK (Rho-kinase), an effector molecule of RhoA, phosphorylates the myosin binding subunit (MBS) of myosin phosphatase and inhibits the phosphatase activity. This inhibition increases phosphorylation of myosin light chain (MLC) of myosin II, which is suggested to induce RhoA-mediated assembly of str...

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Detalles Bibliográficos
Autores principales: Totsukawa, Go, Yamakita, Yoshihiko, Yamashiro, Shigeko, Hartshorne, David J., Sasaki, Yasuharu, Matsumura, Fumio
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175273/
https://www.ncbi.nlm.nih.gov/pubmed/10953004

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