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Aminoglycoside binding to the HIV-1 RNA dimerization initiation site: thermodynamics and effect on the kissing-loop to duplex conversion

Owing to a striking, and most likely fortuitous, structural and sequence similarity with the bacterial 16 S ribosomal A site, the RNA kissing-loop complex formed by the HIV-1 genomic RNA dimerization initiation site (DIS) specifically binds 4,5-disubstituted 2-deoxystreptamine (2-DOS) aminoglycoside...

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Detalles Bibliográficos
Autores principales:	Bernacchi, Serena, Freisz, Séverine, Maechling, Clarisse, Spiess, Bernard, Marquet, Roland, Dumas, Philippe, Ennifar, Eric
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2007
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175338/ https://www.ncbi.nlm.nih.gov/pubmed/17942426 http://dx.doi.org/10.1093/nar/gkm856

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