3′-Azido-2′,3′-dideoxynucleoside 5′-triphosphates inhibit telomerase activity in vitro, and the corresponding nucleosides cause telomere shortening in human HL60 cells

Telomerase adds telomeric DNA repeats to the ends of linear chromosomal DNA. 3′-Azido-3′-deoxythymidine 5′-triphosphate (AZTTP) is a known telomerase inhibitor. To obtain more selective and potent inhibitors that can be employed as tools for studying telomerase, we investigated the telomerase-inhibi...

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Detalles Bibliográficos
Autores principales: Liu, Xiaohong, Takahashi, Hazuki, Harada, Yoko, Ogawara, Tsukasa, Ogimura, Yuta, Mizushina, Yoshiyuku, Saneyoshi, Mineo, Yamaguchi, Toyofumi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175342/
https://www.ncbi.nlm.nih.gov/pubmed/17942424
http://dx.doi.org/10.1093/nar/gkm859

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