Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors

BORIS, like other members of the ‘cancer/testis antigen’ family, is normally expressed in testicular germ cells and repressed in somatic cells, but is aberrantly activated in cancers. To understand regulatory mechanisms governing human BORIS expression, we characterized its 5′-flanking region. Using...

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Detalles Bibliográficos
Autores principales: Renaud, Stéphanie, Pugacheva, Elena M., Delgado, M. Dolores, Braunschweig, Richard, Abdullaev, Ziedulla, Loukinov, Dmitri, Benhattar, Jean, Lobanenkov, Victor
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175345/
https://www.ncbi.nlm.nih.gov/pubmed/17962299
http://dx.doi.org/10.1093/nar/gkm896

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