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An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation

Transcriptional gene silencing (TGS) can be achieved by small RNAs targeted to upstream promoter regions. Previously we characterized siRNAs targeted to the HIV-1 long terminal repeat (LTR) promoter at site 247, and found that a 21-base antisense strand of siRNA-247 (LTR-247as) suppressed LTR-mediat...

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Detalles Bibliográficos
Autores principales:	Weinberg, Marc S., Barichievy, Samantha, Schaffer, Lana, Han, Jiang, Morris, Kevin V.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2007
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175361/ https://www.ncbi.nlm.nih.gov/pubmed/17959645 http://dx.doi.org/10.1093/nar/gkm847

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