A Mitochondrial Kinase Complex Is Essential to Mediate an ERK1/2-Dependent Phosphorylation of a Key Regulatory Protein in Steroid Biosynthesis

ERK1/2 is known to be involved in hormone-stimulated steroid synthesis, but its exact roles and the underlying mechanisms remain elusive. Both ERK1/2 phosphorylation and steroidogenesis may be triggered by cAMP/cAMP-dependent protein kinase (PKA)-dependent and-independent mechanisms; however, ERK1/2...

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Detalles Bibliográficos
Autores principales: Poderoso, Cecilia, Converso, Daniela P., Maloberti, Paula, Duarte, Alejandra, Neuman, Isabel, Galli, Soledad, Maciel, Fabiana Cornejo, Paz, Cristina, Carreras, María C., Poderoso, Juan J., Podestá, Ernesto J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175533/
https://www.ncbi.nlm.nih.gov/pubmed/18197253
http://dx.doi.org/10.1371/journal.pone.0001443

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