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Altered oscillatory brain dynamics after repeated traumatic stress
BACKGROUND: Repeated traumatic experiences, e.g. torture and war, lead to functional and structural cerebral changes, which should be detectable in cortical dynamics. Abnormal slow waves produced within circumscribed brain regions during a resting state have been associated with lesioned neural circ...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176059/ https://www.ncbi.nlm.nih.gov/pubmed/17941996 http://dx.doi.org/10.1186/1471-244X-7-56 |
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author | Kolassa, Iris-Tatjana Wienbruch, Christian Neuner, Frank Schauer, Maggie Ruf, Martina Odenwald, Michael Elbert, Thomas |
author_facet | Kolassa, Iris-Tatjana Wienbruch, Christian Neuner, Frank Schauer, Maggie Ruf, Martina Odenwald, Michael Elbert, Thomas |
author_sort | Kolassa, Iris-Tatjana |
collection | PubMed |
description | BACKGROUND: Repeated traumatic experiences, e.g. torture and war, lead to functional and structural cerebral changes, which should be detectable in cortical dynamics. Abnormal slow waves produced within circumscribed brain regions during a resting state have been associated with lesioned neural circuitry in neurological disorders and more recently also in mental illness. METHODS: Using magnetoencephalographic (MEG-based) source imaging, we mapped abnormal distributions of generators of slow waves in 97 survivors of torture and war with posttraumatic stress disorder (PTSD) in comparison to 97 controls. RESULTS: PTSD patients showed elevated production of focally generated slow waves (1–4 Hz), particularly in left temporal brain regions, with peak activities in the region of the insula. Furthermore, differential slow wave activity in right frontal areas was found in PTSD patients compared to controls. CONCLUSION: The insula, as a site of multimodal convergence, could play a key role in understanding the pathophysiology of PTSD, possibly accounting for what has been called posttraumatic alexithymia, i.e., reduced ability to identify, express and regulate emotional responses to reminders of traumatic events. Differences in activity in right frontal areas may indicate a dysfunctional PFC, which may lead to diminished extinction of conditioned fear and reduced inhibition of the amygdala. |
format | Text |
id | pubmed-2176059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-21760592008-01-09 Altered oscillatory brain dynamics after repeated traumatic stress Kolassa, Iris-Tatjana Wienbruch, Christian Neuner, Frank Schauer, Maggie Ruf, Martina Odenwald, Michael Elbert, Thomas BMC Psychiatry Research Article BACKGROUND: Repeated traumatic experiences, e.g. torture and war, lead to functional and structural cerebral changes, which should be detectable in cortical dynamics. Abnormal slow waves produced within circumscribed brain regions during a resting state have been associated with lesioned neural circuitry in neurological disorders and more recently also in mental illness. METHODS: Using magnetoencephalographic (MEG-based) source imaging, we mapped abnormal distributions of generators of slow waves in 97 survivors of torture and war with posttraumatic stress disorder (PTSD) in comparison to 97 controls. RESULTS: PTSD patients showed elevated production of focally generated slow waves (1–4 Hz), particularly in left temporal brain regions, with peak activities in the region of the insula. Furthermore, differential slow wave activity in right frontal areas was found in PTSD patients compared to controls. CONCLUSION: The insula, as a site of multimodal convergence, could play a key role in understanding the pathophysiology of PTSD, possibly accounting for what has been called posttraumatic alexithymia, i.e., reduced ability to identify, express and regulate emotional responses to reminders of traumatic events. Differences in activity in right frontal areas may indicate a dysfunctional PFC, which may lead to diminished extinction of conditioned fear and reduced inhibition of the amygdala. BioMed Central 2007-10-17 /pmc/articles/PMC2176059/ /pubmed/17941996 http://dx.doi.org/10.1186/1471-244X-7-56 Text en Copyright © 2007 Kolassa et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kolassa, Iris-Tatjana Wienbruch, Christian Neuner, Frank Schauer, Maggie Ruf, Martina Odenwald, Michael Elbert, Thomas Altered oscillatory brain dynamics after repeated traumatic stress |
title | Altered oscillatory brain dynamics after repeated traumatic stress |
title_full | Altered oscillatory brain dynamics after repeated traumatic stress |
title_fullStr | Altered oscillatory brain dynamics after repeated traumatic stress |
title_full_unstemmed | Altered oscillatory brain dynamics after repeated traumatic stress |
title_short | Altered oscillatory brain dynamics after repeated traumatic stress |
title_sort | altered oscillatory brain dynamics after repeated traumatic stress |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176059/ https://www.ncbi.nlm.nih.gov/pubmed/17941996 http://dx.doi.org/10.1186/1471-244X-7-56 |
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