THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS : A DIRECT STUDY OF THE ISOLATED PERFUSED RAT LIVER WITH THE AID OF LYSINE-ε-C(14)

A direct study of the isolated rat liver perfused with oxygenated blood containing amino acids and lysine-ε-C(14) has yielded facts indicating that the liver synthesizes practically all the plasma fibrinogen, the albumin fraction, and probably more than 80 per cent of the plasma globulin fraction. T...

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Detalles Bibliográficos
Autores principales: Miller, L. L., Bly, C. G., Watson, M. L., Bale, W. F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1951
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180336/
https://www.ncbi.nlm.nih.gov/pubmed/14888824
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author Miller, L. L.
Bly, C. G.
Watson, M. L.
Bale, W. F.
author_facet Miller, L. L.
Bly, C. G.
Watson, M. L.
Bale, W. F.
author_sort Miller, L. L.
collection PubMed
description A direct study of the isolated rat liver perfused with oxygenated blood containing amino acids and lysine-ε-C(14) has yielded facts indicating that the liver synthesizes practically all the plasma fibrinogen, the albumin fraction, and probably more than 80 per cent of the plasma globulin fraction. The response of the isolated perfused liver in protein synthesis is qualitatively and quantitatively analogous to that of the intact animal, notably in (a) the ability to discriminate between natural L-lysine and D-lysine, (b) the per cent of isotopic amino acid converted to CO(2), (c) the per cent utilized in liver and plasma protein synthesis. The results obtained with the perfused liver are compared and contrasted with those reported for tissue homogenates, minces, and slices.
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spelling pubmed-21803362008-04-17 THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS : A DIRECT STUDY OF THE ISOLATED PERFUSED RAT LIVER WITH THE AID OF LYSINE-ε-C(14) Miller, L. L. Bly, C. G. Watson, M. L. Bale, W. F. J Exp Med Article A direct study of the isolated rat liver perfused with oxygenated blood containing amino acids and lysine-ε-C(14) has yielded facts indicating that the liver synthesizes practically all the plasma fibrinogen, the albumin fraction, and probably more than 80 per cent of the plasma globulin fraction. The response of the isolated perfused liver in protein synthesis is qualitatively and quantitatively analogous to that of the intact animal, notably in (a) the ability to discriminate between natural L-lysine and D-lysine, (b) the per cent of isotopic amino acid converted to CO(2), (c) the per cent utilized in liver and plasma protein synthesis. The results obtained with the perfused liver are compared and contrasted with those reported for tissue homogenates, minces, and slices. The Rockefeller University Press 1951-10-31 /pmc/articles/PMC2180336/ /pubmed/14888824 Text en Copyright © Copyright, 1951, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Miller, L. L.
Bly, C. G.
Watson, M. L.
Bale, W. F.
THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS : A DIRECT STUDY OF THE ISOLATED PERFUSED RAT LIVER WITH THE AID OF LYSINE-ε-C(14)
title THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS : A DIRECT STUDY OF THE ISOLATED PERFUSED RAT LIVER WITH THE AID OF LYSINE-ε-C(14)
title_full THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS : A DIRECT STUDY OF THE ISOLATED PERFUSED RAT LIVER WITH THE AID OF LYSINE-ε-C(14)
title_fullStr THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS : A DIRECT STUDY OF THE ISOLATED PERFUSED RAT LIVER WITH THE AID OF LYSINE-ε-C(14)
title_full_unstemmed THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS : A DIRECT STUDY OF THE ISOLATED PERFUSED RAT LIVER WITH THE AID OF LYSINE-ε-C(14)
title_short THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS : A DIRECT STUDY OF THE ISOLATED PERFUSED RAT LIVER WITH THE AID OF LYSINE-ε-C(14)
title_sort dominant role of the liver in plasma protein synthesis : a direct study of the isolated perfused rat liver with the aid of lysine-ε-c(14)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180336/
https://www.ncbi.nlm.nih.gov/pubmed/14888824
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