SYNTHESIS OF ALL PLASMA PROTEIN FRACTIONS EXCEPT GAMMA GLOBULINS BY THE LIVER : THE USE OF ZONE ELECTROPHORESIS AND LYSINE-ε-C(14)TO DEFINE THE PLASMA PROTEINS SYNTHESIZED BY THE ISOLATED PERFUSED LIVER

Lysine-ε-C(14)-labeled plasma proteins produced by the normal rat and the isolated perfused rat liver have been fractionated by preparative zone electrophoresis. The isolated perfused liver incorporates lysine-ε-C(14) into the plasma albumin, alpha globulin, and beta globulin (including fibrinogen)...

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Detalles Bibliográficos
Autores principales: Miller, Leon L., Bale, William F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1954
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180344/
https://www.ncbi.nlm.nih.gov/pubmed/13130789
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author Miller, Leon L.
Bale, William F.
author_facet Miller, Leon L.
Bale, William F.
author_sort Miller, Leon L.
collection PubMed
description Lysine-ε-C(14)-labeled plasma proteins produced by the normal rat and the isolated perfused rat liver have been fractionated by preparative zone electrophoresis. The isolated perfused liver incorporates lysine-ε-C(14) into the plasma albumin, alpha globulin, and beta globulin (including fibrinogen) fractions. No significant C(14) incorporation into the trichloracetic acid-precipitable proteins of the gamma globulin fraction was observed. Presumptive evidence indicates that the alpha globulins turn over more rapidly than any other major plasma protein fraction. The increased production of gamma globulins in liver disease is discussed.
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spelling pubmed-21803442008-04-17 SYNTHESIS OF ALL PLASMA PROTEIN FRACTIONS EXCEPT GAMMA GLOBULINS BY THE LIVER : THE USE OF ZONE ELECTROPHORESIS AND LYSINE-ε-C(14)TO DEFINE THE PLASMA PROTEINS SYNTHESIZED BY THE ISOLATED PERFUSED LIVER Miller, Leon L. Bale, William F. J Exp Med Article Lysine-ε-C(14)-labeled plasma proteins produced by the normal rat and the isolated perfused rat liver have been fractionated by preparative zone electrophoresis. The isolated perfused liver incorporates lysine-ε-C(14) into the plasma albumin, alpha globulin, and beta globulin (including fibrinogen) fractions. No significant C(14) incorporation into the trichloracetic acid-precipitable proteins of the gamma globulin fraction was observed. Presumptive evidence indicates that the alpha globulins turn over more rapidly than any other major plasma protein fraction. The increased production of gamma globulins in liver disease is discussed. The Rockefeller University Press 1954-01-31 /pmc/articles/PMC2180344/ /pubmed/13130789 Text en Copyright © Copyright, 1954, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Miller, Leon L.
Bale, William F.
SYNTHESIS OF ALL PLASMA PROTEIN FRACTIONS EXCEPT GAMMA GLOBULINS BY THE LIVER : THE USE OF ZONE ELECTROPHORESIS AND LYSINE-ε-C(14)TO DEFINE THE PLASMA PROTEINS SYNTHESIZED BY THE ISOLATED PERFUSED LIVER
title SYNTHESIS OF ALL PLASMA PROTEIN FRACTIONS EXCEPT GAMMA GLOBULINS BY THE LIVER : THE USE OF ZONE ELECTROPHORESIS AND LYSINE-ε-C(14)TO DEFINE THE PLASMA PROTEINS SYNTHESIZED BY THE ISOLATED PERFUSED LIVER
title_full SYNTHESIS OF ALL PLASMA PROTEIN FRACTIONS EXCEPT GAMMA GLOBULINS BY THE LIVER : THE USE OF ZONE ELECTROPHORESIS AND LYSINE-ε-C(14)TO DEFINE THE PLASMA PROTEINS SYNTHESIZED BY THE ISOLATED PERFUSED LIVER
title_fullStr SYNTHESIS OF ALL PLASMA PROTEIN FRACTIONS EXCEPT GAMMA GLOBULINS BY THE LIVER : THE USE OF ZONE ELECTROPHORESIS AND LYSINE-ε-C(14)TO DEFINE THE PLASMA PROTEINS SYNTHESIZED BY THE ISOLATED PERFUSED LIVER
title_full_unstemmed SYNTHESIS OF ALL PLASMA PROTEIN FRACTIONS EXCEPT GAMMA GLOBULINS BY THE LIVER : THE USE OF ZONE ELECTROPHORESIS AND LYSINE-ε-C(14)TO DEFINE THE PLASMA PROTEINS SYNTHESIZED BY THE ISOLATED PERFUSED LIVER
title_short SYNTHESIS OF ALL PLASMA PROTEIN FRACTIONS EXCEPT GAMMA GLOBULINS BY THE LIVER : THE USE OF ZONE ELECTROPHORESIS AND LYSINE-ε-C(14)TO DEFINE THE PLASMA PROTEINS SYNTHESIZED BY THE ISOLATED PERFUSED LIVER
title_sort synthesis of all plasma protein fractions except gamma globulins by the liver : the use of zone electrophoresis and lysine-ε-c(14)to define the plasma proteins synthesized by the isolated perfused liver
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180344/
https://www.ncbi.nlm.nih.gov/pubmed/13130789
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AT balewilliamf synthesisofallplasmaproteinfractionsexceptgammaglobulinsbythelivertheuseofzoneelectrophoresisandlysineec14todefinetheplasmaproteinssynthesizedbytheisolatedperfusedliver

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