THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS : I. PASSIVE TRANSFER OF ISOIMMUNE SERUM TO CONDITIONED HOSTS

Gross and microscopic observations of skin homograft rejection carried out in cortisone-conditioned and non-conditioned rabbits seem to indicate that humoral antibodies play an important role in the phenomenon. Thus, local administration of isoimmune serum to animals bearing skin homografts resulted...

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Detalles Bibliográficos
Autores principales: Kretschmer, Roberto R., Peréz-Tamayo, Ruy
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1961
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180364/
https://www.ncbi.nlm.nih.gov/pubmed/19867199
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author Kretschmer, Roberto R.
Peréz-Tamayo, Ruy
author_facet Kretschmer, Roberto R.
Peréz-Tamayo, Ruy
author_sort Kretschmer, Roberto R.
collection PubMed
description Gross and microscopic observations of skin homograft rejection carried out in cortisone-conditioned and non-conditioned rabbits seem to indicate that humoral antibodies play an important role in the phenomenon. Thus, local administration of isoimmune serum to animals bearing skin homografts resulted in a significantly earlier rejection of that particular test graft without modifying the course of a neighboring control-skin graft. This result appears to support the idea that homograft rejection is not only due to cellular antibodies but to a combination of both humoral and cellular immune responses, which should not be regarded as completely unrelated.
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spelling pubmed-21803642008-04-17 THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS : I. PASSIVE TRANSFER OF ISOIMMUNE SERUM TO CONDITIONED HOSTS Kretschmer, Roberto R. Peréz-Tamayo, Ruy J Exp Med Article Gross and microscopic observations of skin homograft rejection carried out in cortisone-conditioned and non-conditioned rabbits seem to indicate that humoral antibodies play an important role in the phenomenon. Thus, local administration of isoimmune serum to animals bearing skin homografts resulted in a significantly earlier rejection of that particular test graft without modifying the course of a neighboring control-skin graft. This result appears to support the idea that homograft rejection is not only due to cellular antibodies but to a combination of both humoral and cellular immune responses, which should not be regarded as completely unrelated. The Rockefeller University Press 1961-09-30 /pmc/articles/PMC2180364/ /pubmed/19867199 Text en Copyright © Copyright, 1961, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Kretschmer, Roberto R.
Peréz-Tamayo, Ruy
THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS : I. PASSIVE TRANSFER OF ISOIMMUNE SERUM TO CONDITIONED HOSTS
title THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS : I. PASSIVE TRANSFER OF ISOIMMUNE SERUM TO CONDITIONED HOSTS
title_full THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS : I. PASSIVE TRANSFER OF ISOIMMUNE SERUM TO CONDITIONED HOSTS
title_fullStr THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS : I. PASSIVE TRANSFER OF ISOIMMUNE SERUM TO CONDITIONED HOSTS
title_full_unstemmed THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS : I. PASSIVE TRANSFER OF ISOIMMUNE SERUM TO CONDITIONED HOSTS
title_short THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS : I. PASSIVE TRANSFER OF ISOIMMUNE SERUM TO CONDITIONED HOSTS
title_sort role of humoral antibodies in rejection of skin homografts in rabbits : i. passive transfer of isoimmune serum to conditioned hosts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180364/
https://www.ncbi.nlm.nih.gov/pubmed/19867199
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