THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : I. THE CELLULAR SURFACE

Immersion of chorioallantoic membranes infected by influenza virus in ferritin-conjugated antibody globulin prior to fixation permits recognition of viral antigen at the cellular surface. In some cases the antigen is confined to sites at which viral particles appear to be in process of release, wher...

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Detalles Bibliográficos
Autores principales: Morgan, Councilman, Hsu, Konrad C., Rifkind, Richard A., Knox, Alice W., Rose, Harry M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1961
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180370/
https://www.ncbi.nlm.nih.gov/pubmed/19867207
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author Morgan, Councilman
Hsu, Konrad C.
Rifkind, Richard A.
Knox, Alice W.
Rose, Harry M.
author_facet Morgan, Councilman
Hsu, Konrad C.
Rifkind, Richard A.
Knox, Alice W.
Rose, Harry M.
author_sort Morgan, Councilman
collection PubMed
description Immersion of chorioallantoic membranes infected by influenza virus in ferritin-conjugated antibody globulin prior to fixation permits recognition of viral antigen at the cellular surface. In some cases the antigen is confined to sites at which viral particles appear to be in process of release, whereas in others it is present along the entire cellular surface. During infection part or all of the cellular membrane presumably is transformed so that it contains the antigenic and structural components which coat the virus during emergence. It is suggested that detached fragments of cytoplasm possessing surface hemagglutinin but incapable of initiating infection constitute at least one form of "incomplete virus."
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spelling pubmed-21803702008-04-17 THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : I. THE CELLULAR SURFACE Morgan, Councilman Hsu, Konrad C. Rifkind, Richard A. Knox, Alice W. Rose, Harry M. J Exp Med Article Immersion of chorioallantoic membranes infected by influenza virus in ferritin-conjugated antibody globulin prior to fixation permits recognition of viral antigen at the cellular surface. In some cases the antigen is confined to sites at which viral particles appear to be in process of release, whereas in others it is present along the entire cellular surface. During infection part or all of the cellular membrane presumably is transformed so that it contains the antigenic and structural components which coat the virus during emergence. It is suggested that detached fragments of cytoplasm possessing surface hemagglutinin but incapable of initiating infection constitute at least one form of "incomplete virus." The Rockefeller University Press 1961-10-31 /pmc/articles/PMC2180370/ /pubmed/19867207 Text en Copyright © Copyright, 1961, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Morgan, Councilman
Hsu, Konrad C.
Rifkind, Richard A.
Knox, Alice W.
Rose, Harry M.
THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : I. THE CELLULAR SURFACE
title THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : I. THE CELLULAR SURFACE
title_full THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : I. THE CELLULAR SURFACE
title_fullStr THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : I. THE CELLULAR SURFACE
title_full_unstemmed THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : I. THE CELLULAR SURFACE
title_short THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : I. THE CELLULAR SURFACE
title_sort application of ferritin-conjugated antibody to electron microscopic studies of influenza virus in infected cells : i. the cellular surface
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180370/
https://www.ncbi.nlm.nih.gov/pubmed/19867207
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