THE INDUCTION OF A RHEUMATOID FACTOR-LIKE SUBSTANCE IN RABBITS

Hyperimmunization of two groups of rabbits with killed Escherichia coli and Bacillus subtilis has resulted in the formation of a serum factor (RFLS) which resembled the human rheumatoid factor. It was a heat-stable protein that migrated electrophoretically in the gamma-beta globulin range and sedime...

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Detalles Bibliográficos
Autores principales: Abruzzo, John L., Christians, Charles L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1961
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180373/
https://www.ncbi.nlm.nih.gov/pubmed/13859099
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author Abruzzo, John L.
Christians, Charles L.
author_facet Abruzzo, John L.
Christians, Charles L.
author_sort Abruzzo, John L.
collection PubMed
description Hyperimmunization of two groups of rabbits with killed Escherichia coli and Bacillus subtilis has resulted in the formation of a serum factor (RFLS) which resembled the human rheumatoid factor. It was a heat-stable protein that migrated electrophoretically in the gamma-beta globulin range and sedimented rapidly with ultracentrifugation. The serologic properties of the RFLS were destroyed by mercaptoethanol. It reacted primarily with rabbit gamma globulin in an aggregated state (immune complexes or physically aggregated gamma globulin) and demonstrated cross-reactivity with human gamma globulin.
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spelling pubmed-21803732008-04-17 THE INDUCTION OF A RHEUMATOID FACTOR-LIKE SUBSTANCE IN RABBITS Abruzzo, John L. Christians, Charles L. J Exp Med Article Hyperimmunization of two groups of rabbits with killed Escherichia coli and Bacillus subtilis has resulted in the formation of a serum factor (RFLS) which resembled the human rheumatoid factor. It was a heat-stable protein that migrated electrophoretically in the gamma-beta globulin range and sedimented rapidly with ultracentrifugation. The serologic properties of the RFLS were destroyed by mercaptoethanol. It reacted primarily with rabbit gamma globulin in an aggregated state (immune complexes or physically aggregated gamma globulin) and demonstrated cross-reactivity with human gamma globulin. The Rockefeller University Press 1961-10-31 /pmc/articles/PMC2180373/ /pubmed/13859099 Text en Copyright © Copyright, 1961, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Abruzzo, John L.
Christians, Charles L.
THE INDUCTION OF A RHEUMATOID FACTOR-LIKE SUBSTANCE IN RABBITS
title THE INDUCTION OF A RHEUMATOID FACTOR-LIKE SUBSTANCE IN RABBITS
title_full THE INDUCTION OF A RHEUMATOID FACTOR-LIKE SUBSTANCE IN RABBITS
title_fullStr THE INDUCTION OF A RHEUMATOID FACTOR-LIKE SUBSTANCE IN RABBITS
title_full_unstemmed THE INDUCTION OF A RHEUMATOID FACTOR-LIKE SUBSTANCE IN RABBITS
title_short THE INDUCTION OF A RHEUMATOID FACTOR-LIKE SUBSTANCE IN RABBITS
title_sort induction of a rheumatoid factor-like substance in rabbits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180373/
https://www.ncbi.nlm.nih.gov/pubmed/13859099
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