EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : I. PLATELET AGGREGATION AND RELEASE OF PLATELET FACTORS IN VITRO

Incubation of platelet-rich rabbit plasma with E. coli endotoxin at 37°C results in platelet aggregation and transfer of platelet 5-hydroxytryptamine to plasma. Release of 5HT is influenced by dose of endotoxin, type of anticoagulant, and temperature of incubation. A heat-labile plasma factor is nec...

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Detalles Bibliográficos
Autores principales: Des Prez, Roger M., Horowitz, Herbert I., Hook, Edward W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1961
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180403/
https://www.ncbi.nlm.nih.gov/pubmed/13885652
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author Des Prez, Roger M.
Horowitz, Herbert I.
Hook, Edward W.
author_facet Des Prez, Roger M.
Horowitz, Herbert I.
Hook, Edward W.
author_sort Des Prez, Roger M.
collection PubMed
description Incubation of platelet-rich rabbit plasma with E. coli endotoxin at 37°C results in platelet aggregation and transfer of platelet 5-hydroxytryptamine to plasma. Release of 5HT is influenced by dose of endotoxin, type of anticoagulant, and temperature of incubation. A heat-labile plasma factor is necessary for the platelet-endotoxin interaction. Additional studies have shown that incubation of endotoxin with platelet-rich rabbit plasma also results in release of platelet phospholipid and bactericidins active against B. subtilis.
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spelling pubmed-21804032008-04-17 EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : I. PLATELET AGGREGATION AND RELEASE OF PLATELET FACTORS IN VITRO Des Prez, Roger M. Horowitz, Herbert I. Hook, Edward W. J Exp Med Article Incubation of platelet-rich rabbit plasma with E. coli endotoxin at 37°C results in platelet aggregation and transfer of platelet 5-hydroxytryptamine to plasma. Release of 5HT is influenced by dose of endotoxin, type of anticoagulant, and temperature of incubation. A heat-labile plasma factor is necessary for the platelet-endotoxin interaction. Additional studies have shown that incubation of endotoxin with platelet-rich rabbit plasma also results in release of platelet phospholipid and bactericidins active against B. subtilis. The Rockefeller University Press 1961-11-30 /pmc/articles/PMC2180403/ /pubmed/13885652 Text en Copyright © Copyright, 1961, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Des Prez, Roger M.
Horowitz, Herbert I.
Hook, Edward W.
EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : I. PLATELET AGGREGATION AND RELEASE OF PLATELET FACTORS IN VITRO
title EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : I. PLATELET AGGREGATION AND RELEASE OF PLATELET FACTORS IN VITRO
title_full EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : I. PLATELET AGGREGATION AND RELEASE OF PLATELET FACTORS IN VITRO
title_fullStr EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : I. PLATELET AGGREGATION AND RELEASE OF PLATELET FACTORS IN VITRO
title_full_unstemmed EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : I. PLATELET AGGREGATION AND RELEASE OF PLATELET FACTORS IN VITRO
title_short EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : I. PLATELET AGGREGATION AND RELEASE OF PLATELET FACTORS IN VITRO
title_sort effects of bacterial endotoxin on rabbit platelets : i. platelet aggregation and release of platelet factors in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180403/
https://www.ncbi.nlm.nih.gov/pubmed/13885652
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AT hookedwardw effectsofbacterialendotoxinonrabbitplateletsiplateletaggregationandreleaseofplateletfactorsinvitro

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