STUDIES ON ARTIFICIAL ANTIGENS : I. ANTIGENICITY OF DNP-POLYLYSINE AND DNP COPOLYMER OF LYSINE AND GLUTAMIC ACID IN GUINEA PIGS

Dinitrophenyl conjugates of poly-L-lysine, varying in percentage conjugation and molecular weight have been found to induce skin reactivity and precipitating antibodies in guinea pigs. At best, 40 per cent of immunized animals developed delayed and immediate responses to DNP-polylysine, which is bel...

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Detalles Bibliográficos
Autores principales: Kantor, Fred S., Ojeda, Antonio, Benacerraf, Baruj
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180431/
https://www.ncbi.nlm.nih.gov/pubmed/14030666
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author Kantor, Fred S.
Ojeda, Antonio
Benacerraf, Baruj
author_facet Kantor, Fred S.
Ojeda, Antonio
Benacerraf, Baruj
author_sort Kantor, Fred S.
collection PubMed
description Dinitrophenyl conjugates of poly-L-lysine, varying in percentage conjugation and molecular weight have been found to induce skin reactivity and precipitating antibodies in guinea pigs. At best, 40 per cent of immunized animals developed delayed and immediate responses to DNP-polylysine, which is believed to reflect constitutional differences among the animals assayed. Only those animals capable of responding to DNP-polylysine, responded to an immunologically distinct poly-α-amino acid consisting of glutamyl and lysyl residues ("copolymer glu-lys"). The percentage of animals responding to the DNP-polylysine antigen decreased as the degree of DNP conjugation increased.
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spelling pubmed-21804312008-04-17 STUDIES ON ARTIFICIAL ANTIGENS : I. ANTIGENICITY OF DNP-POLYLYSINE AND DNP COPOLYMER OF LYSINE AND GLUTAMIC ACID IN GUINEA PIGS Kantor, Fred S. Ojeda, Antonio Benacerraf, Baruj J Exp Med Article Dinitrophenyl conjugates of poly-L-lysine, varying in percentage conjugation and molecular weight have been found to induce skin reactivity and precipitating antibodies in guinea pigs. At best, 40 per cent of immunized animals developed delayed and immediate responses to DNP-polylysine, which is believed to reflect constitutional differences among the animals assayed. Only those animals capable of responding to DNP-polylysine, responded to an immunologically distinct poly-α-amino acid consisting of glutamyl and lysyl residues ("copolymer glu-lys"). The percentage of animals responding to the DNP-polylysine antigen decreased as the degree of DNP conjugation increased. The Rockefeller University Press 1963-01-01 /pmc/articles/PMC2180431/ /pubmed/14030666 Text en Copyright ©, 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Kantor, Fred S.
Ojeda, Antonio
Benacerraf, Baruj
STUDIES ON ARTIFICIAL ANTIGENS : I. ANTIGENICITY OF DNP-POLYLYSINE AND DNP COPOLYMER OF LYSINE AND GLUTAMIC ACID IN GUINEA PIGS
title STUDIES ON ARTIFICIAL ANTIGENS : I. ANTIGENICITY OF DNP-POLYLYSINE AND DNP COPOLYMER OF LYSINE AND GLUTAMIC ACID IN GUINEA PIGS
title_full STUDIES ON ARTIFICIAL ANTIGENS : I. ANTIGENICITY OF DNP-POLYLYSINE AND DNP COPOLYMER OF LYSINE AND GLUTAMIC ACID IN GUINEA PIGS
title_fullStr STUDIES ON ARTIFICIAL ANTIGENS : I. ANTIGENICITY OF DNP-POLYLYSINE AND DNP COPOLYMER OF LYSINE AND GLUTAMIC ACID IN GUINEA PIGS
title_full_unstemmed STUDIES ON ARTIFICIAL ANTIGENS : I. ANTIGENICITY OF DNP-POLYLYSINE AND DNP COPOLYMER OF LYSINE AND GLUTAMIC ACID IN GUINEA PIGS
title_short STUDIES ON ARTIFICIAL ANTIGENS : I. ANTIGENICITY OF DNP-POLYLYSINE AND DNP COPOLYMER OF LYSINE AND GLUTAMIC ACID IN GUINEA PIGS
title_sort studies on artificial antigens : i. antigenicity of dnp-polylysine and dnp copolymer of lysine and glutamic acid in guinea pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180431/
https://www.ncbi.nlm.nih.gov/pubmed/14030666
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