AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM : V. INDUCTION OF INTERFERON BY HELENINE

Helenine, a substance obtained from broth cultures of Penicillium funiculosum and known to exert a protective effect in vivo in experimental animals against several unrelated viruses, has been shown to elicit the formation in cell cultures and in intact mice of an inhibitor of viral plaque formation...

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Detalles Bibliográficos
Autores principales: Rytel, Michael W., Shope, Richard E., Kilbourne, Edwin D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1966
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180457/
https://www.ncbi.nlm.nih.gov/pubmed/5933468
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author Rytel, Michael W.
Shope, Richard E.
Kilbourne, Edwin D.
author_facet Rytel, Michael W.
Shope, Richard E.
Kilbourne, Edwin D.
author_sort Rytel, Michael W.
collection PubMed
description Helenine, a substance obtained from broth cultures of Penicillium funiculosum and known to exert a protective effect in vivo in experimental animals against several unrelated viruses, has been shown to elicit the formation in cell cultures and in intact mice of an inhibitor of viral plaque formation. Because the biological and chemical characteristics of the viral inhibitor induced by helenine are similar to those of interferon, it is suggested that the antiviral effect of helenine may be mediated through the formation of interferon.
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spelling pubmed-21804572008-04-17 AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM : V. INDUCTION OF INTERFERON BY HELENINE Rytel, Michael W. Shope, Richard E. Kilbourne, Edwin D. J Exp Med Article Helenine, a substance obtained from broth cultures of Penicillium funiculosum and known to exert a protective effect in vivo in experimental animals against several unrelated viruses, has been shown to elicit the formation in cell cultures and in intact mice of an inhibitor of viral plaque formation. Because the biological and chemical characteristics of the viral inhibitor induced by helenine are similar to those of interferon, it is suggested that the antiviral effect of helenine may be mediated through the formation of interferon. The Rockefeller University Press 1966-03-31 /pmc/articles/PMC2180457/ /pubmed/5933468 Text en Copyright © 1966 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Rytel, Michael W.
Shope, Richard E.
Kilbourne, Edwin D.
AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM : V. INDUCTION OF INTERFERON BY HELENINE
title AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM : V. INDUCTION OF INTERFERON BY HELENINE
title_full AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM : V. INDUCTION OF INTERFERON BY HELENINE
title_fullStr AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM : V. INDUCTION OF INTERFERON BY HELENINE
title_full_unstemmed AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM : V. INDUCTION OF INTERFERON BY HELENINE
title_short AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM : V. INDUCTION OF INTERFERON BY HELENINE
title_sort antiviral substance from penicillium funiculosum : v. induction of interferon by helenine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180457/
https://www.ncbi.nlm.nih.gov/pubmed/5933468
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