Cargando…

THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION

A dietary depletion of magnesium in rats leads to the production in the thin limb of Henle's loop of the nephrons of spherical microliths composed of a matrix of PAS-positive substances and calcium phosphate (3). These microliths grow by accretion to form intranephronic calculi. The classical p...

Descripción completa

Detalles Bibliográficos
Autores principales: Oliver, J., MacDowell, M., Whang, R., Welt, L. G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1966
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180476/
https://www.ncbi.nlm.nih.gov/pubmed/5919693
_version_ 1782145555173998592
author Oliver, J.
MacDowell, M.
Whang, R.
Welt, L. G.
author_facet Oliver, J.
MacDowell, M.
Whang, R.
Welt, L. G.
author_sort Oliver, J.
collection PubMed
description A dietary depletion of magnesium in rats leads to the production in the thin limb of Henle's loop of the nephrons of spherical microliths composed of a matrix of PAS-positive substances and calcium phosphate (3). These microliths grow by accretion to form intranephronic calculi. The classical pathological syndrome of clinical nephrolithiasis is thus reproduced within the nephron; to wit, the origin of the calculus at a certain level, local traumatic damage at the site of its origin, passage with the fluid flow down the urinary passages, lodgment of the calculus at some restricting point, obstruction of fluid flow and the usual consequent localized intrarenal "hydronephrotic" alterations of regressive atrophic cellular dysplasias within the nephron. To the classical description of the two forms of urinary lithiases occurring in the bladder and in the renal pelvis must therefore be added a third form, intranephronic calculosis. From the first origin of a microlith to its ultimate form as a calculus its organized structure is characterized by its matrix (PAS-positive materials) in which the periodic precipitation of crystalline mineral (Ca(++), PO(3) (---)) occurs in a pattern simulating Liesegang rings.
format Text
id pubmed-2180476
institution National Center for Biotechnology Information
language English
publishDate 1966
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21804762008-04-17 THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION Oliver, J. MacDowell, M. Whang, R. Welt, L. G. J Exp Med Article A dietary depletion of magnesium in rats leads to the production in the thin limb of Henle's loop of the nephrons of spherical microliths composed of a matrix of PAS-positive substances and calcium phosphate (3). These microliths grow by accretion to form intranephronic calculi. The classical pathological syndrome of clinical nephrolithiasis is thus reproduced within the nephron; to wit, the origin of the calculus at a certain level, local traumatic damage at the site of its origin, passage with the fluid flow down the urinary passages, lodgment of the calculus at some restricting point, obstruction of fluid flow and the usual consequent localized intrarenal "hydronephrotic" alterations of regressive atrophic cellular dysplasias within the nephron. To the classical description of the two forms of urinary lithiases occurring in the bladder and in the renal pelvis must therefore be added a third form, intranephronic calculosis. From the first origin of a microlith to its ultimate form as a calculus its organized structure is characterized by its matrix (PAS-positive materials) in which the periodic precipitation of crystalline mineral (Ca(++), PO(3) (---)) occurs in a pattern simulating Liesegang rings. The Rockefeller University Press 1966-08-01 /pmc/articles/PMC2180476/ /pubmed/5919693 Text en Copyright © 1966 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Oliver, J.
MacDowell, M.
Whang, R.
Welt, L. G.
THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION
title THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION
title_full THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION
title_fullStr THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION
title_full_unstemmed THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION
title_short THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION
title_sort renal lesions of electrolyte imbalance : iv. the intranephronic calculosis of experimental magnesium depletion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180476/
https://www.ncbi.nlm.nih.gov/pubmed/5919693
work_keys_str_mv AT oliverj therenallesionsofelectrolyteimbalanceivtheintranephroniccalculosisofexperimentalmagnesiumdepletion
AT macdowellm therenallesionsofelectrolyteimbalanceivtheintranephroniccalculosisofexperimentalmagnesiumdepletion
AT whangr therenallesionsofelectrolyteimbalanceivtheintranephroniccalculosisofexperimentalmagnesiumdepletion
AT weltlg therenallesionsofelectrolyteimbalanceivtheintranephroniccalculosisofexperimentalmagnesiumdepletion
AT oliverj renallesionsofelectrolyteimbalanceivtheintranephroniccalculosisofexperimentalmagnesiumdepletion
AT macdowellm renallesionsofelectrolyteimbalanceivtheintranephroniccalculosisofexperimentalmagnesiumdepletion
AT whangr renallesionsofelectrolyteimbalanceivtheintranephroniccalculosisofexperimentalmagnesiumdepletion
AT weltlg renallesionsofelectrolyteimbalanceivtheintranephroniccalculosisofexperimentalmagnesiumdepletion