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THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION
A dietary depletion of magnesium in rats leads to the production in the thin limb of Henle's loop of the nephrons of spherical microliths composed of a matrix of PAS-positive substances and calcium phosphate (3). These microliths grow by accretion to form intranephronic calculi. The classical p...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1966
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180476/ https://www.ncbi.nlm.nih.gov/pubmed/5919693 |
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author | Oliver, J. MacDowell, M. Whang, R. Welt, L. G. |
author_facet | Oliver, J. MacDowell, M. Whang, R. Welt, L. G. |
author_sort | Oliver, J. |
collection | PubMed |
description | A dietary depletion of magnesium in rats leads to the production in the thin limb of Henle's loop of the nephrons of spherical microliths composed of a matrix of PAS-positive substances and calcium phosphate (3). These microliths grow by accretion to form intranephronic calculi. The classical pathological syndrome of clinical nephrolithiasis is thus reproduced within the nephron; to wit, the origin of the calculus at a certain level, local traumatic damage at the site of its origin, passage with the fluid flow down the urinary passages, lodgment of the calculus at some restricting point, obstruction of fluid flow and the usual consequent localized intrarenal "hydronephrotic" alterations of regressive atrophic cellular dysplasias within the nephron. To the classical description of the two forms of urinary lithiases occurring in the bladder and in the renal pelvis must therefore be added a third form, intranephronic calculosis. From the first origin of a microlith to its ultimate form as a calculus its organized structure is characterized by its matrix (PAS-positive materials) in which the periodic precipitation of crystalline mineral (Ca(++), PO(3) (---)) occurs in a pattern simulating Liesegang rings. |
format | Text |
id | pubmed-2180476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1966 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21804762008-04-17 THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION Oliver, J. MacDowell, M. Whang, R. Welt, L. G. J Exp Med Article A dietary depletion of magnesium in rats leads to the production in the thin limb of Henle's loop of the nephrons of spherical microliths composed of a matrix of PAS-positive substances and calcium phosphate (3). These microliths grow by accretion to form intranephronic calculi. The classical pathological syndrome of clinical nephrolithiasis is thus reproduced within the nephron; to wit, the origin of the calculus at a certain level, local traumatic damage at the site of its origin, passage with the fluid flow down the urinary passages, lodgment of the calculus at some restricting point, obstruction of fluid flow and the usual consequent localized intrarenal "hydronephrotic" alterations of regressive atrophic cellular dysplasias within the nephron. To the classical description of the two forms of urinary lithiases occurring in the bladder and in the renal pelvis must therefore be added a third form, intranephronic calculosis. From the first origin of a microlith to its ultimate form as a calculus its organized structure is characterized by its matrix (PAS-positive materials) in which the periodic precipitation of crystalline mineral (Ca(++), PO(3) (---)) occurs in a pattern simulating Liesegang rings. The Rockefeller University Press 1966-08-01 /pmc/articles/PMC2180476/ /pubmed/5919693 Text en Copyright © 1966 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Oliver, J. MacDowell, M. Whang, R. Welt, L. G. THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION |
title | THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION |
title_full | THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION |
title_fullStr | THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION |
title_full_unstemmed | THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION |
title_short | THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : IV. THE INTRANEPHRONIC CALCULOSIS OF EXPERIMENTAL MAGNESIUM DEPLETION |
title_sort | renal lesions of electrolyte imbalance : iv. the intranephronic calculosis of experimental magnesium depletion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180476/ https://www.ncbi.nlm.nih.gov/pubmed/5919693 |
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