PROLIFERATION OF B AND T CELLS IN MIXED LYMPHOCYTE CULTURES

Electrophoretically fractionated CBA/Ca spleen T cells alone respond to allogeneic cells in one-way MLC and to PHA. They do not respond to E. coli LPS. B cells alone do not respond to allogeneic cells nor to PHA, but do respond to LPS. When karyotypically distinguishable syngeneic mixtures of T and...

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Detalles Bibliográficos
Autores principales: Andersson, Leif C., Nordling, Stig, Häyry, Pekka
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180546/
https://www.ncbi.nlm.nih.gov/pubmed/4268630
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author Andersson, Leif C.
Nordling, Stig
Häyry, Pekka
author_facet Andersson, Leif C.
Nordling, Stig
Häyry, Pekka
author_sort Andersson, Leif C.
collection PubMed
description Electrophoretically fractionated CBA/Ca spleen T cells alone respond to allogeneic cells in one-way MLC and to PHA. They do not respond to E. coli LPS. B cells alone do not respond to allogeneic cells nor to PHA, but do respond to LPS. When karyotypically distinguishable syngeneic mixtures of T and B lymphocytes are stimulated with allogeneic cells, at the most 5% of mitoses on 5–9th culture day are of B cell origin. This indicates that B cells are not substantially recruited to proliferate in the MLC.
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spelling pubmed-21805462008-04-17 PROLIFERATION OF B AND T CELLS IN MIXED LYMPHOCYTE CULTURES Andersson, Leif C. Nordling, Stig Häyry, Pekka J Exp Med Brief Definitive Reports Electrophoretically fractionated CBA/Ca spleen T cells alone respond to allogeneic cells in one-way MLC and to PHA. They do not respond to E. coli LPS. B cells alone do not respond to allogeneic cells nor to PHA, but do respond to LPS. When karyotypically distinguishable syngeneic mixtures of T and B lymphocytes are stimulated with allogeneic cells, at the most 5% of mitoses on 5–9th culture day are of B cell origin. This indicates that B cells are not substantially recruited to proliferate in the MLC. The Rockefeller University Press 1973-07-01 /pmc/articles/PMC2180546/ /pubmed/4268630 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Andersson, Leif C.
Nordling, Stig
Häyry, Pekka
PROLIFERATION OF B AND T CELLS IN MIXED LYMPHOCYTE CULTURES
title PROLIFERATION OF B AND T CELLS IN MIXED LYMPHOCYTE CULTURES
title_full PROLIFERATION OF B AND T CELLS IN MIXED LYMPHOCYTE CULTURES
title_fullStr PROLIFERATION OF B AND T CELLS IN MIXED LYMPHOCYTE CULTURES
title_full_unstemmed PROLIFERATION OF B AND T CELLS IN MIXED LYMPHOCYTE CULTURES
title_short PROLIFERATION OF B AND T CELLS IN MIXED LYMPHOCYTE CULTURES
title_sort proliferation of b and t cells in mixed lymphocyte cultures
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180546/
https://www.ncbi.nlm.nih.gov/pubmed/4268630
work_keys_str_mv AT anderssonleifc proliferationofbandtcellsinmixedlymphocytecultures
AT nordlingstig proliferationofbandtcellsinmixedlymphocytecultures
AT hayrypekka proliferationofbandtcellsinmixedlymphocytecultures

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