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MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY
The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse µ-chain antibody and goat antimouse γ1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 an...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1973
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180547/ https://www.ncbi.nlm.nih.gov/pubmed/4736831 |
| Sumario: | The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse µ-chain antibody and goat antimouse γ1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 anti-DNP antibody (16% and 14%, respectively) was considerably higher than that which would be predicted by a random distribution. It would thus appear that IgM and IgG1 antibody can be made by the clonal progeny of a single precursor cell. |
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