MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY

The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse µ-chain antibody and goat antimouse γ1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 an...

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Detalles Bibliográficos
Autores principales: Press, Joan L., Klinman, Norman R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180547/
https://www.ncbi.nlm.nih.gov/pubmed/4736831
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author Press, Joan L.
Klinman, Norman R.
author_facet Press, Joan L.
Klinman, Norman R.
author_sort Press, Joan L.
collection PubMed
description The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse µ-chain antibody and goat antimouse γ1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 anti-DNP antibody (16% and 14%, respectively) was considerably higher than that which would be predicted by a random distribution. It would thus appear that IgM and IgG1 antibody can be made by the clonal progeny of a single precursor cell.
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spelling pubmed-21805472008-04-17 MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY Press, Joan L. Klinman, Norman R. J Exp Med Brief Definitive Reports The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse µ-chain antibody and goat antimouse γ1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 anti-DNP antibody (16% and 14%, respectively) was considerably higher than that which would be predicted by a random distribution. It would thus appear that IgM and IgG1 antibody can be made by the clonal progeny of a single precursor cell. The Rockefeller University Press 1973-07-01 /pmc/articles/PMC2180547/ /pubmed/4736831 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Press, Joan L.
Klinman, Norman R.
MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY
title MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY
title_full MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY
title_fullStr MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY
title_full_unstemmed MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY
title_short MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY
title_sort monoclonal production of both igm and igg1 antihapten antibody
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180547/
https://www.ncbi.nlm.nih.gov/pubmed/4736831
work_keys_str_mv AT pressjoanl monoclonalproductionofbothigmandigg1antihaptenantibody
AT klinmannormanr monoclonalproductionofbothigmandigg1antihaptenantibody

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