MONOCLONAL MACROGLOBULINEMIA IN NZB/NZW F(1) MICE

Serum monoclonal macroglobulins were detected in over 30% of NZB/NZW F(1) mice greater than 11 mo of age. The monoclonal nature of the IgM was shown by restricted electrophoretic mobility, characteristic appearance on immunoelectrophoresis, restriction to a single light chain type, and ability to in...

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Detalles Bibliográficos
Autores principales: Sugai, Susumu, Pillarisetty, Rao, Talal, Norman
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180563/
https://www.ncbi.nlm.nih.gov/pubmed/4200650
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author Sugai, Susumu
Pillarisetty, Rao
Talal, Norman
author_facet Sugai, Susumu
Pillarisetty, Rao
Talal, Norman
author_sort Sugai, Susumu
collection PubMed
description Serum monoclonal macroglobulins were detected in over 30% of NZB/NZW F(1) mice greater than 11 mo of age. The monoclonal nature of the IgM was shown by restricted electrophoretic mobility, characteristic appearance on immunoelectrophoresis, restriction to a single light chain type, and ability to induce anti-idiotypic antisera. The monoclonal macroglobulins were separated from antibodies to DNA and RNA that migrated in the 7S region of sucrose gradients. Enlarged lymph nodes were often present in mice with monoclonal IgM, and a transplantable IgM-producing lymphoid tumor was established from the spleen of one animal.
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spelling pubmed-21805632008-04-17 MONOCLONAL MACROGLOBULINEMIA IN NZB/NZW F(1) MICE Sugai, Susumu Pillarisetty, Rao Talal, Norman J Exp Med Article Serum monoclonal macroglobulins were detected in over 30% of NZB/NZW F(1) mice greater than 11 mo of age. The monoclonal nature of the IgM was shown by restricted electrophoretic mobility, characteristic appearance on immunoelectrophoresis, restriction to a single light chain type, and ability to induce anti-idiotypic antisera. The monoclonal macroglobulins were separated from antibodies to DNA and RNA that migrated in the 7S region of sucrose gradients. Enlarged lymph nodes were often present in mice with monoclonal IgM, and a transplantable IgM-producing lymphoid tumor was established from the spleen of one animal. The Rockefeller University Press 1973-10-01 /pmc/articles/PMC2180563/ /pubmed/4200650 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Sugai, Susumu
Pillarisetty, Rao
Talal, Norman
MONOCLONAL MACROGLOBULINEMIA IN NZB/NZW F(1) MICE
title MONOCLONAL MACROGLOBULINEMIA IN NZB/NZW F(1) MICE
title_full MONOCLONAL MACROGLOBULINEMIA IN NZB/NZW F(1) MICE
title_fullStr MONOCLONAL MACROGLOBULINEMIA IN NZB/NZW F(1) MICE
title_full_unstemmed MONOCLONAL MACROGLOBULINEMIA IN NZB/NZW F(1) MICE
title_short MONOCLONAL MACROGLOBULINEMIA IN NZB/NZW F(1) MICE
title_sort monoclonal macroglobulinemia in nzb/nzw f(1) mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180563/
https://www.ncbi.nlm.nih.gov/pubmed/4200650
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AT pillarisettyrao monoclonalmacroglobulinemiainnzbnzwf1mice
AT talalnorman monoclonalmacroglobulinemiainnzbnzwf1mice

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