LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS : IN VITRO STIMULATION IN RESPONSE TO VIRAL-INFECTED CELL LINES

Efforts to stimulate lymphocytes from measles seropositive and two patients with subacute sclerosing panencephalitis (SSPE) with either commercially available measles virus or virus isolated from a known case of SSPE failed to show any significant data using a microculture assay. Similar results wer...

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Autores principales: Thurman, G. B., Ahmed, A., Strong, D. M., Knudsen, R. C., Grace, W. R., Sell, K. W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180568/
https://www.ncbi.nlm.nih.gov/pubmed/4355279
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author Thurman, G. B.
Ahmed, A.
Strong, D. M.
Knudsen, R. C.
Grace, W. R.
Sell, K. W.
author_facet Thurman, G. B.
Ahmed, A.
Strong, D. M.
Knudsen, R. C.
Grace, W. R.
Sell, K. W.
author_sort Thurman, G. B.
collection PubMed
description Efforts to stimulate lymphocytes from measles seropositive and two patients with subacute sclerosing panencephalitis (SSPE) with either commercially available measles virus or virus isolated from a known case of SSPE failed to show any significant data using a microculture assay. Similar results were obtained using lymphocytes from two patients with active cytomegalovirus (CMV) infections and CMV seropositive individuals using CMV suspensions. On the other hand, lymphocytes from the patients with subacute sclerosing panencephalitis exhibited in vitro blastogenesis in culture with SSPE virus-infected HeLa cells. Similarly, lymphocytes from the CMV-infected patients demonstrated blastogenesis when cocultivated with CMV-infected WI-38 cells. This affords a new method for determining the cell-mediated immune capacity of patients with "slow" virus diseases.
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spelling pubmed-21805682008-04-17 LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS : IN VITRO STIMULATION IN RESPONSE TO VIRAL-INFECTED CELL LINES Thurman, G. B. Ahmed, A. Strong, D. M. Knudsen, R. C. Grace, W. R. Sell, K. W. J Exp Med Article Efforts to stimulate lymphocytes from measles seropositive and two patients with subacute sclerosing panencephalitis (SSPE) with either commercially available measles virus or virus isolated from a known case of SSPE failed to show any significant data using a microculture assay. Similar results were obtained using lymphocytes from two patients with active cytomegalovirus (CMV) infections and CMV seropositive individuals using CMV suspensions. On the other hand, lymphocytes from the patients with subacute sclerosing panencephalitis exhibited in vitro blastogenesis in culture with SSPE virus-infected HeLa cells. Similarly, lymphocytes from the CMV-infected patients demonstrated blastogenesis when cocultivated with CMV-infected WI-38 cells. This affords a new method for determining the cell-mediated immune capacity of patients with "slow" virus diseases. The Rockefeller University Press 1973-10-01 /pmc/articles/PMC2180568/ /pubmed/4355279 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Thurman, G. B.
Ahmed, A.
Strong, D. M.
Knudsen, R. C.
Grace, W. R.
Sell, K. W.
LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS : IN VITRO STIMULATION IN RESPONSE TO VIRAL-INFECTED CELL LINES
title LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS : IN VITRO STIMULATION IN RESPONSE TO VIRAL-INFECTED CELL LINES
title_full LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS : IN VITRO STIMULATION IN RESPONSE TO VIRAL-INFECTED CELL LINES
title_fullStr LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS : IN VITRO STIMULATION IN RESPONSE TO VIRAL-INFECTED CELL LINES
title_full_unstemmed LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS : IN VITRO STIMULATION IN RESPONSE TO VIRAL-INFECTED CELL LINES
title_short LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS : IN VITRO STIMULATION IN RESPONSE TO VIRAL-INFECTED CELL LINES
title_sort lymphocyte activation in subacute sclerosing panencephalitis virus and cytomegalovirus infections : in vitro stimulation in response to viral-infected cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180568/
https://www.ncbi.nlm.nih.gov/pubmed/4355279
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