ANTIBODIES TO A SPECIFIC SURFACE ANTIGEN OF T CELLS IN HUMAN SERA INHIBITING MIXED LEUKOCYTE CULTURE REACTIONS

Surface radioiodination of lymphocytes by the lactoperoxidase procedure has permitted demonstration of an assortment of different antibodies to lymphocytes in the sera of patients with systemic lupus erythematosus. One type of antibody proved of special interest because it appeared to be associated...

Descripción completa

Detalles Bibliográficos
Autores principales: Wernet, Peter, Kunkel, Henry G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180576/
https://www.ncbi.nlm.nih.gov/pubmed/4542734
_version_ 1782145578778492928
author Wernet, Peter
Kunkel, Henry G.
author_facet Wernet, Peter
Kunkel, Henry G.
author_sort Wernet, Peter
collection PubMed
description Surface radioiodination of lymphocytes by the lactoperoxidase procedure has permitted demonstration of an assortment of different antibodies to lymphocytes in the sera of patients with systemic lupus erythematosus. One type of antibody proved of special interest because it appeared to be associated with inhibition of the responder cells in the mixed leukocyte culture reactions. This reacted with an antigen on T cells and thymocytes which on sodium dodecyl sulfate acrylamide gel electrophoresis showed a molecular weight of approximately 15,000 daltons. The possible relation of this antigen to T cell receptors and products of immune response genes is discussed.
format Text
id pubmed-2180576
institution National Center for Biotechnology Information
language English
publishDate 1973
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21805762008-04-17 ANTIBODIES TO A SPECIFIC SURFACE ANTIGEN OF T CELLS IN HUMAN SERA INHIBITING MIXED LEUKOCYTE CULTURE REACTIONS Wernet, Peter Kunkel, Henry G. J Exp Med Brief Definitive Reports Surface radioiodination of lymphocytes by the lactoperoxidase procedure has permitted demonstration of an assortment of different antibodies to lymphocytes in the sera of patients with systemic lupus erythematosus. One type of antibody proved of special interest because it appeared to be associated with inhibition of the responder cells in the mixed leukocyte culture reactions. This reacted with an antigen on T cells and thymocytes which on sodium dodecyl sulfate acrylamide gel electrophoresis showed a molecular weight of approximately 15,000 daltons. The possible relation of this antigen to T cell receptors and products of immune response genes is discussed. The Rockefeller University Press 1973-10-01 /pmc/articles/PMC2180576/ /pubmed/4542734 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Wernet, Peter
Kunkel, Henry G.
ANTIBODIES TO A SPECIFIC SURFACE ANTIGEN OF T CELLS IN HUMAN SERA INHIBITING MIXED LEUKOCYTE CULTURE REACTIONS
title ANTIBODIES TO A SPECIFIC SURFACE ANTIGEN OF T CELLS IN HUMAN SERA INHIBITING MIXED LEUKOCYTE CULTURE REACTIONS
title_full ANTIBODIES TO A SPECIFIC SURFACE ANTIGEN OF T CELLS IN HUMAN SERA INHIBITING MIXED LEUKOCYTE CULTURE REACTIONS
title_fullStr ANTIBODIES TO A SPECIFIC SURFACE ANTIGEN OF T CELLS IN HUMAN SERA INHIBITING MIXED LEUKOCYTE CULTURE REACTIONS
title_full_unstemmed ANTIBODIES TO A SPECIFIC SURFACE ANTIGEN OF T CELLS IN HUMAN SERA INHIBITING MIXED LEUKOCYTE CULTURE REACTIONS
title_short ANTIBODIES TO A SPECIFIC SURFACE ANTIGEN OF T CELLS IN HUMAN SERA INHIBITING MIXED LEUKOCYTE CULTURE REACTIONS
title_sort antibodies to a specific surface antigen of t cells in human sera inhibiting mixed leukocyte culture reactions
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180576/
https://www.ncbi.nlm.nih.gov/pubmed/4542734
work_keys_str_mv AT wernetpeter antibodiestoaspecificsurfaceantigenoftcellsinhumanserainhibitingmixedleukocyteculturereactions
AT kunkelhenryg antibodiestoaspecificsurfaceantigenoftcellsinhumanserainhibitingmixedleukocyteculturereactions

Ejemplares similares