T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells

The Ly and Ia phenotypes of T lymphocytes involved in the in vitro generation of helper and suppressor cells were identified. The precursors of both cells are found in adult thymectomized spleen. Helper precursors are Ly-1+2-3-Ia-, while suppressor precursors are Ly- 1-2+3+Ia-, although the suppress...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180645/
https://www.ncbi.nlm.nih.gov/pubmed/67169
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description The Ly and Ia phenotypes of T lymphocytes involved in the in vitro generation of helper and suppressor cells were identified. The precursors of both cells are found in adult thymectomized spleen. Helper precursors are Ly-1+2-3-Ia-, while suppressor precursors are Ly- 1-2+3+Ia-, although the suppressor effector is Ia+. In both cases a second 'amplifier' cell is required for differentiation of precursors to occur. This cell is found in anti-lymphocyte serum-treated spleen and has the phenotype Ly-1+2+3+Ia-.
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spelling pubmed-21806452008-04-17 T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells J Exp Med Articles The Ly and Ia phenotypes of T lymphocytes involved in the in vitro generation of helper and suppressor cells were identified. The precursors of both cells are found in adult thymectomized spleen. Helper precursors are Ly-1+2-3-Ia-, while suppressor precursors are Ly- 1-2+3+Ia-, although the suppressor effector is Ia+. In both cases a second 'amplifier' cell is required for differentiation of precursors to occur. This cell is found in anti-lymphocyte serum-treated spleen and has the phenotype Ly-1+2+3+Ia-. The Rockefeller University Press 1977-04-01 /pmc/articles/PMC2180645/ /pubmed/67169 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells
title T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells
title_full T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells
title_fullStr T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells
title_full_unstemmed T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells
title_short T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells
title_sort t-t interactions in the induction of suppressor and helper t cells: analysis of membrane phenotype of precursor and amplifier cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180645/
https://www.ncbi.nlm.nih.gov/pubmed/67169

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