Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells

Phagocytosis of bacteria stimulates "professional" phagocytes to produce and release endogenous pyrogen (EP), the protein that mediates fever. To determine whether "nonprofessional" phagocytes also have this capacity, mouse and human fibroblasts and HeLa cells were cultured after...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180710/
https://www.ncbi.nlm.nih.gov/pubmed/233905
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collection PubMed
description Phagocytosis of bacteria stimulates "professional" phagocytes to produce and release endogenous pyrogen (EP), the protein that mediates fever. To determine whether "nonprofessional" phagocytes also have this capacity, mouse and human fibroblasts and HeLa cells were cultured after ingestion of latex or chicken erythrocytes (CE), and EP release into culture supernate measured by mouse assay. No detectable pyrogen was released by these cell types after phagocytosis, whereas both latex and CE stimulated EP production by cultured mouse macrophages. These studies support the hypothesis that only professional phagocytes of bone marrow origin synthesize EP and induce fever.
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spelling pubmed-21807102008-04-17 Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells J Exp Med Articles Phagocytosis of bacteria stimulates "professional" phagocytes to produce and release endogenous pyrogen (EP), the protein that mediates fever. To determine whether "nonprofessional" phagocytes also have this capacity, mouse and human fibroblasts and HeLa cells were cultured after ingestion of latex or chicken erythrocytes (CE), and EP release into culture supernate measured by mouse assay. No detectable pyrogen was released by these cell types after phagocytosis, whereas both latex and CE stimulated EP production by cultured mouse macrophages. These studies support the hypothesis that only professional phagocytes of bone marrow origin synthesize EP and induce fever. The Rockefeller University Press 1977-03-01 /pmc/articles/PMC2180710/ /pubmed/233905 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells
title Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells
title_full Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells
title_fullStr Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells
title_full_unstemmed Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells
title_short Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells
title_sort differences in pyrogen production by mononuclear phagocytes and by fibroblasts or hela cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180710/
https://www.ncbi.nlm.nih.gov/pubmed/233905

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