Prevention of IgG2a production as a result of allotype-specific interaction between T and B cells

BALB/c T cells, which can prevent normal C57BL IgG2a allotype (G2) production of Ig-congenic partner mice (C.B mice), are shown capable of preventing the growth and G2 production of a C.B plasmacytoma (CBPC 101). Such cytotoxic or suppressor T cells are clearly allotype- specific (G2 Tcs cells). And...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180716/
https://www.ncbi.nlm.nih.gov/pubmed/233911
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collection PubMed
description BALB/c T cells, which can prevent normal C57BL IgG2a allotype (G2) production of Ig-congenic partner mice (C.B mice), are shown capable of preventing the growth and G2 production of a C.B plasmacytoma (CBPC 101). Such cytotoxic or suppressor T cells are clearly allotype- specific (G2 Tcs cells). And since CBPC 101 B cells do not require specific helper T cells in order to grow, we infer that G2-bearing B cells (normal or neoplastic) must be the direct target of G2 Tcs cells. This mode of T cell prevention of allotype production contrasts that reported for suppressor T cells in (BALB/c x SJL)F1 mice.
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spelling pubmed-21807162008-04-17 Prevention of IgG2a production as a result of allotype-specific interaction between T and B cells J Exp Med Articles BALB/c T cells, which can prevent normal C57BL IgG2a allotype (G2) production of Ig-congenic partner mice (C.B mice), are shown capable of preventing the growth and G2 production of a C.B plasmacytoma (CBPC 101). Such cytotoxic or suppressor T cells are clearly allotype- specific (G2 Tcs cells). And since CBPC 101 B cells do not require specific helper T cells in order to grow, we infer that G2-bearing B cells (normal or neoplastic) must be the direct target of G2 Tcs cells. This mode of T cell prevention of allotype production contrasts that reported for suppressor T cells in (BALB/c x SJL)F1 mice. The Rockefeller University Press 1977-03-01 /pmc/articles/PMC2180716/ /pubmed/233911 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Prevention of IgG2a production as a result of allotype-specific interaction between T and B cells
title Prevention of IgG2a production as a result of allotype-specific interaction between T and B cells
title_full Prevention of IgG2a production as a result of allotype-specific interaction between T and B cells
title_fullStr Prevention of IgG2a production as a result of allotype-specific interaction between T and B cells
title_full_unstemmed Prevention of IgG2a production as a result of allotype-specific interaction between T and B cells
title_short Prevention of IgG2a production as a result of allotype-specific interaction between T and B cells
title_sort prevention of igg2a production as a result of allotype-specific interaction between t and b cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180716/
https://www.ncbi.nlm.nih.gov/pubmed/233911

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